Di-tert-butylphosphate potassium salt
Di-tert-butylphosphate potassium salt (CAS: 33494-80-3; Formula: C8H18KO4P; MW: 248.30) is a chemical compound with significant utility in advanced material synthesis and drug development. It serves as a crucial intermediate in the creation of N-phosphonooxymethyl prodrugs designed to enhance bioavailability. Furthermore, it is employed in the synthesis of Nasicon-type phosphates, materials vital for fast ion conductors and ceramics exhibiting low thermal expansion.
- IUPAC
- Phosphoric acid di-tert-butyl ester, potassium salt
- Synonyms
- Phosphoric acid di-tert-butyl ester, potassium salt

Prodrug Synthesis
Used as an intermediate in the preparation of N-phosphonooxymethyl prodrugs. These prodrugs are formulated to improve the oral bioavailability of active pharmaceutical ingredients.
Nasicon-type Phosphate Synthesis
Key component in synthesizing Nasicon-type phosphates, such as KTi2(PO4)3. These materials are essential for applications requiring fast ion conductors.
Ceramic Materials
Involved in the development of ceramics with low thermal expansion properties, leveraging its role in Nasicon-type phosphate structures.
| Molecular weight | 248.30 |
|---|---|
| Empirical formula | C8H18KO4P |
| Storage temperature | 2-8°C |
| Application | Utilized as an intermediate to prepare N-phosphonooxymethyl prodrugs, which increase bioavailability, and to prepare Nasicon-type phosphates (i.e., KTi2(PO4)3) used in fast ion conductors with low thermal expansion ceramics. |
| Melting point | 247-252 °C |

Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Water hazard class (WGK, DE) | 3 |
|---|---|
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Di-tert-butylphosphate potassium salt primarily used for?
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Di-tert-butylphosphate potassium salt is primarily used as an intermediate in the synthesis of N-phosphonooxymethyl prodrugs to improve bioavailability and in the preparation of Nasicon-type phosphates for fast ion conductors and low thermal expansion ceramics.
What are the CAS number and formula for Di-tert-butylphosphate potassium salt?
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The CAS number is 33494-80-3, and the empirical formula is C8H18KO4P.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Di-tert-butylphosphate potassium salt typically at a research or technical grade. We do not represent this product as USP, BP, EP, or other pharmacopoeia grades unless explicitly stated.
How should Di-tert-butylphosphate potassium salt be handled and stored?
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Di-tert-butylphosphate potassium salt is an irritant to the skin, eyes, and respiratory tract (H315-H319-H335). Handle with appropriate personal protective equipment in a well-ventilated area. Store at 2-8°C as indicated.
How is Di-tert-butylphosphate potassium salt packed and shipped?
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Di-tert-butylphosphate potassium salt is carefully packed to ensure stability during transit and is exported globally by Tech Serve Solutions.
How can I request a sample or quote for Di-tert-butylphosphate potassium salt?
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To request a sample or a quote, please contact our sales team via the website or direct inquiry, providing the product name and CAS number (33494-80-3).
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