Di-tert-butylneopentylphosphonium tetrafluoroborate
Di-tert-butylneopentylphosphonium tetrafluoroborate (CAS: 886059-84-3), with the molecular formula C13H30BF4P and a molecular weight of 304.16, is a phosphine ligand notable for its application in palladium-catalyzed cross-coupling reactions. It has demonstrated superior performance compared to tris(tert-butyl)phosphine in aminations involving aryl bromides and chlorides, making it a valuable reagent in advanced chemical synthesis.
- IUPAC
- Di-tert-butylneopentylphosphine tetrafluoroborate
Palladium-Catalyzed Aminations
This phosphonium salt serves as an effective ligand in palladium-catalyzed amination reactions, facilitating the formation of carbon-nitrogen bonds. It has shown improved efficacy over other common phosphine ligands when reacting with challenging substrates like aryl chlorides and bromides.
Cross-Coupling Reactions
As a component in catalysis, Di-tert-butylneopentylphosphonium tetrafluoroborate is employed in various cross-coupling processes critical for organic synthesis. Its unique structural features contribute to enhanced catalytic activity and selectivity in complex chemical transformations.
Chemical Synthesis Reagent
Utilised in general chemical synthesis, this compound acts as a specialised ligand in transition metal catalysis. It aids in the construction of complex organic molecules for research and development in fields such as pharmaceuticals and materials science.
| Molecular weight | 304.16 |
|---|---|
| Empirical formula | C13H30BF4P |
| Assay | 95% |
| Application | This neopentylphosphine ligand proved to be superior to tris(tert-butyl)phosphine in palladium-catalyzed aminations of aryl bromides and chlorides.2 |
| Melting point | 258-262 °C |
Hazard statements
- H302Harmful if swallowed
- H312Harmful in contact with skin
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 21/22-36/37/38 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Di-tert-butylneopentylphosphonium tetrafluoroborate used for?
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Di-tert-butylneopentylphosphonium tetrafluoroborate is primarily used as a phosphine ligand in palladium-catalyzed amination and cross-coupling reactions, offering superior performance in certain transformations involving aryl halides.
What are the CAS number and formula for Di-tert-butylneopentylphosphonium tetrafluoroborate?
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The CAS number is 886059-84-3 and the empirical formula (Hill notation) is C13H30BF4P.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Di-tert-butylneopentylphosphonium tetrafluoroborate with an assay of 95%. This is a technical/research grade product, and TSS does not represent it as USP, BP, EP, or pharmacopoeia grade.
How should Di-tert-butylneopentylphosphonium tetrafluoroborate be handled safely?
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This compound is harmful if swallowed, in contact with skin, and causes skin and serious eye irritation, and may cause respiratory irritation. Handle with appropriate personal protective equipment, including a dust mask (N95), eyeshields, and gloves. Ensure adequate ventilation. Refer to the Safety Data Sheet for detailed information.
Is Di-tert-butylneopentylphosphonium tetrafluoroborate a controlled substance?
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Based on the provided data, there is no indication that Di-tert-butylneopentylphosphonium tetrafluoroborate is a controlled substance.
How is Di-tert-butylneopentylphosphonium tetrafluoroborate packed and shipped?
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Products are packed and shipped in accordance with international regulations for chemical transport. For specific export details and shipping options, please contact our sales department.
How can I request a quote or sample for Di-tert-butylneopentylphosphonium tetrafluoroborate?
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To request a quote or a sample, please contact the Tech Serve Solutions sales team via our website or direct contact details, specifying the product name and CAS number (886059-84-3).
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