Di-tert-butylchlorophosphine
Di-tert-butylchlorophosphine (CAS: 13716-10-4, Formula: [(CH3)3C]2PCl) is a phosphorus compound with a molecular weight of 180.66 g/mol. This chemical serves as a bulky ligand, notably in combination with Pd(OAc)2, for efficient Suzuki-Miyaura cross-coupling reactions. Its utility extends to various chemical synthesis applications, making it a valuable reagent in catalysis and for the preparation of specialised phosphorus-containing compounds.
![Di-tert-butylchlorophosphine ([(CH3)3C]2PCl) — chemical structure, CAS 13716-10-4; Chemistry, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F13716-10-4.png&w=3840&q=75)
Ligand for Suzuki-Miyaura Coupling
Utilised as a bulky ligand in conjunction with palladium(II) acetate for highly effective Suzuki-Miyaura cross-coupling reactions. It facilitates the coupling of arylboronic acids with aryl bromides and chlorides.
Chemical Synthesis
A key reagent in organic synthesis, particularly for introducing phosphine functionalities into molecules. It is employed in the preparation of diverse organophosphorus compounds.
Catalysis
Functions as a ligand in transition metal catalysis, enhancing reactivity and selectivity in various catalytic cycles, especially those involving palladium.
Phosphorus Precursor
Serves as a precursor for synthesising more complex phosphine ligands and organophosphorus materials.
| Molecular weight | 180.66 |
|---|---|
| Linear formula | [(CH3)3C]2PCl |
| Assay | 96% |
| Boiling point | 48 °C/3 mmHg(lit.) |
| Density | 0.951 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.482(lit.) |
| Application | Bulky ligand used with Pd(OAc)2 in efficient Suzuki-Miyaura cross-couplings of arylboronic acids with aryl bromides and chlorides.1 |
Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 62 °C / 143.6 °F |
| Transport (UN / ADR) | UN 3265 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Ligand For | Suzuki-Miyaura Coupling |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Di-tert-butylchlorophosphine used for?
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Di-tert-butylchlorophosphine is primarily used as a bulky ligand in palladium-catalysed Suzuki-Miyaura cross-coupling reactions, particularly for coupling arylboronic acids with aryl bromides and chlorides. It is also applied in general chemical synthesis and as a phosphorus precursor.
What are the CAS number and formula for Di-tert-butylchlorophosphine?
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The CAS number for Di-tert-butylchlorophosphine is 13716-10-4, and its linear formula is [(CH3)3C]2PCl.
What grade and purity does Tech Serve Solutions supply for Di-tert-butylchlorophosphine?
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Tech Serve Solutions supplies Di-tert-butylchlorophosphine with an assay of 96%. This product is not represented as USP, BP, or EP grade.
What are the primary safety concerns when handling Di-tert-butylchlorophosphine?
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Di-tert-butylchlorophosphine is classified under GHS05 with the signal word 'Danger' due to hazard statement H314 (Causes severe skin burns and eye damage). Appropriate personal protective equipment, including face shields, goggles, gloves, and suitable respirators, must be used, and handling should occur in a well-ventilated area or fume hood.
How is Di-tert-butylchlorophosphine typically packed and exported?
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Di-tert-butylchlorophosphine is packed in compliance with UN 3265, Class 8, Packing Group II regulations for safe transportation. Tech Serve Solutions exports this chemical globally, adhering to all relevant shipping and customs requirements.
How can I request a quote or sample of Di-tert-butylchlorophosphine?
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To request a quote or a sample of Di-tert-butylchlorophosphine, please contact the Tech Serve Solutions sales team via our website or direct contact details, providing your specific requirements.
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