Di-tert-butyl N,N-diisopropylphosphoramidite
Di-tert-butyl N,N-diisopropylphosphoramidite (CAS 137348-86-8) is a phosphine compound with a molecular weight of 277.38 g/mol. This reagent is recognised for its utility in chemical synthesis, particularly as a coupling reagent and in nucleoside chemistry. Its structure, [(CH3)2CH]2NP[OC(CH3)3]2, makes it valuable in catalytic processes and the development of phosphine ligands, contributing to advancements in inorganic chemistry and chemical biology.
- Synonyms
- [(CH3)2CH]2NP[OC(CH3)3]2
![Di-tert-butyl N,N-diisopropylphosphoramidite ([(CH3)2CH]2NP[OC(CH3)3]2) — chemical structure, CAS 137348-86-8; Chemistry, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F137348-86-8.png&w=3840&q=75)
Nucleoside Chemistry
Di-tert-butyl N,N-diisopropylphosphoramidite serves as a key reagent in the synthesis of modified nucleosides. It facilitates the introduction of phosphite triester linkages crucial for oligonucleotide synthesis.
Coupling Reagent
This compound functions as an effective coupling reagent in organic synthesis. It is employed in reactions requiring the formation of specific chemical bonds under controlled conditions.
Phosphine Ligand Precursor
It acts as a valuable precursor for the synthesis of various phosphine ligands. These ligands are essential in transition metal catalysis for a range of chemical transformations.
Catalysis and Inorganic Chemistry
The compound finds applications in catalysis, contributing to advancements in inorganic chemistry. Its properties are leveraged in developing new catalytic systems and exploring inorganic reaction mechanisms.
| Molecular weight | 277.38 |
|---|---|
| Linear formula | [(CH3)2CH]2NP[OC(CH3)3]2 |
| Assay | 95% |
| Boiling point | 85-90 °C/0.2 mmHg(lit.) |
| Density | 0.879 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.444(lit.) |
| Storage temperature | 2-8°C |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 113 °C / 235.4 °F |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Di-tert-butyl N,N-diisopropylphosphoramidite used for?
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Di-tert-butyl N,N-diisopropylphosphoramidite is used in nucleoside chemistry, as a coupling reagent, as a precursor for phosphine ligands, and in catalysis and inorganic chemistry.
What are the CAS number and formula for Di-tert-butyl N,N-diisopropylphosphoramidite?
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The CAS number is 137348-86-8 and the linear formula is [(CH3)2CH]2NP[OC(CH3)3]2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Di-tert-butyl N,N-diisopropylphosphoramidite with an assay of 95%. This product is intended for research and technical use; TSS does not represent it as USP, BP, or EP grade.
What are the safety and handling considerations for this chemical?
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This compound is classified as a Warning, with hazards including skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). Appropriate personal protective equipment, such as eyeshields and suitable gloves, should be worn. Ensure adequate ventilation and refer to the safety data sheet for comprehensive handling guidance.
How is Di-tert-butyl N,N-diisopropylphosphoramidite packed, shipped, and exported?
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Di-tert-butyl N,N-diisopropylphosphoramidite is carefully packed to maintain its integrity during transit. TSS specialises in the global export of fine chemicals, ensuring compliance with all relevant shipping regulations.
How can I request a sample or a quote for Di-tert-butyl N,N-diisopropylphosphoramidite?
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To request a sample or a quote, please contact the Tech Serve Solutions sales team through our website or by calling our customer service line. Please provide the product name and CAS number for prompt service.
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