Di(1-adamantyl)benzylphosphine
Di(1-adamantyl)benzylphosphine (CAS 395116-70-8), a phosphine compound with the molecular formula C27H37P and a molecular weight of 392.56, is a versatile ligand utilised in advanced chemical synthesis. It serves as a key catalyst in various cross-coupling reactions, aminations, and hydroformylations, demonstrating significant utility in asymmetric synthesis and catalysis.
- IUPAC
- cataCXium® ABn
Sonogashira Coupling Reactions
This phosphine ligand is employed as a catalyst in Sonogashira coupling reactions, facilitating the formation of carbon-carbon bonds between terminal alkynes and aryl or vinyl halides. Its application contributes to efficient synthetic routes for complex organic molecules.
Ruthenium-Catalyzed Amination
Di(1-adamantyl)benzylphosphine acts as a catalyst in the ruthenium-catalyzed amination of secondary alcohols with ammonia. This process is important for the synthesis of amines, which are fundamental building blocks in pharmaceuticals and agrochemicals.
Rhodium-Catalyzed Hydroformylation
It functions as a ligand in rhodium-catalyzed regioselective hydroformylation of alkenes. This application is crucial for producing aldehydes from olefins, offering precise control over regioselectivity in industrial chemical processes.
Reductive Carbonylation
The compound finds use as a catalyst in reductive carbonylation reactions. These reactions are valuable for introducing carbonyl groups into organic structures under reducing conditions, often used in the synthesis of esters and amides.
Suzuki Coupling Reactions
Di(1-adamantyl)benzylphosphine is utilised as a catalyst in Suzuki coupling reactions. This palladium-catalyzed process is widely applied for forming carbon-carbon bonds, particularly in the synthesis of biaryl compounds.
| Molecular weight | 392.56 |
|---|---|
| Empirical formula | C27H37P |
| Assay | 95% |
| Application | Catalyst for:• Sonogashira coupling reaction1• Ruthenium-catalyzed amination of secondary alcohols. with ammonia2• Rhodium-catalyzed regioselective hydroformylation of alkenes3• Reductive carbonylation4• Suzuki coupling reaction5 |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Di(1-adamantyl)benzylphosphine used for?
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Di(1-adamantyl)benzylphosphine (CAS 395116-70-8) is primarily used as a catalyst and ligand in various organic synthesis reactions, including Sonogashira coupling, ruthenium-catalyzed amination, rhodium-catalyzed hydroformylation, reductive carbonylation, and Suzuki coupling reactions.
What is the CAS number and formula for Di(1-adamantyl)benzylphosphine?
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The CAS number for Di(1-adamantyl)benzylphosphine is 395116-70-8, and its empirical formula is C27H37P.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Di(1-adamantyl)benzylphosphine with a minimum purity of 95% (assay). This product is intended for research and laboratory use and is not supplied as USP, BP, EP, or any pharmacopoeia grade.
What are the safety and handling requirements for Di(1-adamantyl)benzylphosphine?
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Di(1-adamantyl)benzylphosphine requires appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is recommended. It has a WGK rating of 3 in Germany, indicating a high hazard level.
How can I request a sample or quote for Di(1-adamantyl)benzylphosphine?
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To request a sample or a quotation for Di(1-adamantyl)benzylphosphine, please contact our sales team via the website or direct email, providing your specific requirements and contact details.
Is Di(1-adamantyl)benzylphosphine controlled or scheduled?
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Based on the provided data, there is no indication that Di(1-adamantyl)benzylphosphine is a controlled or scheduled substance.
How is Di(1-adamantyl)benzylphosphine packed, shipped, and exported?
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Tech Serve Solutions packs, ships, and exports Di(1-adamantyl)benzylphosphine in compliance with all relevant national and international regulations for chemical transport. Specific packaging details will be provided upon order confirmation.
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