Di(1-adamantyl)-n-butylphosphine
Di(1-adamantyl)-n-butylphosphine (CAS: 321921-71-5), with the molecular formula C24H39P and a molecular weight of 358.54 g/mol, is a specialized phosphine ligand. It is widely utilised in catalysis, particularly for various cross-coupling reactions. Its bulky adamantyl groups and butyl chain contribute to its effectiveness in promoting challenging bond formations.
- IUPAC
- cataCXium® A
Buchwald-Hartwig Amination
This phosphine ligand is highly effective in catalyzing Buchwald-Hartwig amination reactions, facilitating the formation of carbon-nitrogen bonds with high efficiency and selectivity.
Suzuki-Miyaura Coupling
Di(1-adamantyl)-n-butylphosphine serves as a valuable ligand in Suzuki-Miyaura coupling reactions, enabling the construction of carbon-carbon bonds between aryl or vinyl halides and organoboron compounds.
Heck Reaction
It is employed in the Heck reaction to catalyse the coupling of aryl or vinyl halides with alkenes, forming substituted alkenes. This application is crucial in organic synthesis for building complex molecular architectures.
Sonogashira Coupling
The ligand is utilized in Sonogashira coupling, a process that joins terminal alkynes with aryl or vinyl halides. This reaction is fundamental for synthesizing enynes and other conjugated systems.
Arylations and C-C Bond Formation
More broadly, Di(1-adamantyl)-n-butylphosphine is a versatile ligand for various palladium-catalyzed arylations and other carbon-carbon bond-forming reactions, proving essential in synthetic chemistry.
| Molecular weight | 358.54 |
|---|---|
| Empirical formula | C24H39P |
| Assay | ≥95%95% |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Ligand For | ArylationsBuchwald-Hartwig Cross Coupling ReactionC-C Bond FormationHeck ReactionSonogashira CouplingSuzuki-Miyaura Coupling |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Di(1-adamantyl)-n-butylphosphine used for?
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Di(1-adamantyl)-n-butylphosphine is primarily used as a ligand in various palladium-catalyzed cross-coupling reactions, including Suzuki-Miyaura coupling, Buchwald-Hartwig amination, Heck reaction, and Sonogashira coupling, facilitating the formation of carbon-carbon and carbon-heteroatom bonds.
What is the CAS number and formula for Di(1-adamantyl)-n-butylphosphine?
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The CAS number is 321921-71-5 and the molecular formula is C24H39P.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Di(1-adamantyl)-n-butylphosphine with a purity of ≥95% (95%). We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
What are the safety and handling recommendations for Di(1-adamantyl)-n-butylphosphine?
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For safe handling, it is recommended to wear eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter should be used. The compound is classified with WGK Germany 3, indicating a high hazard to water.
How is Di(1-adamantyl)-n-butylphosphine packed and shipped?
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Di(1-adamantyl)-n-butylphosphine is carefully packed and exported by Tech Serve Solutions, adhering to all necessary regulations for safe transport of chemical goods.
How can I request a quote or sample for Di(1-adamantyl)-n-butylphosphine?
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To request a quote or a sample of Di(1-adamantyl)-n-butylphosphine, please contact our sales team through the website or by phone.
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