Di-tert-butylphosphine
Di-tert-butylphosphine (CAS: 819-19-2) is an organophosphorus compound with the linear formula (CH3)3CPHC(CH3)3 and a molecular weight of 146.21 g/mol. It is a key ligand and reagent utilized in various catalytic processes and chemical synthesis applications. Its properties make it valuable in promoting specific organic transformations, particularly in cross-coupling reactions.
- IUPAC
- Bis(tert-butyl)phosphine,HP(t-Bu)2
- Synonyms
- Bis(tert-butyl)phosphineHP(t-Bu)2
Catalysis
Di-tert-butylphosphine serves as a crucial ligand in homogeneous catalysis. It is employed in transition metal-catalyzed reactions, enhancing catalyst activity and selectivity.
Buchwald-Hartwig Cross-Coupling
This compound is a widely used phosphine ligand for the Buchwald-Hartwig amination and related cross-coupling reactions. It facilitates the formation of carbon-nitrogen and carbon-oxygen bonds.
Heck Reaction
In the Heck reaction, Di-tert-butylphosphine can act as a ligand to promote palladium-catalyzed coupling between aryl or vinyl halides and alkenes.
Suzuki-Miyaura Coupling
It is also applicable as a ligand in Suzuki-Miyaura coupling reactions, enabling the formation of carbon-carbon bonds between organoboron compounds and organic halides.
Chemical Synthesis
Beyond its catalytic roles, Di-tert-butylphosphine is a versatile reagent in organic synthesis, used in the preparation of complex molecules and organophosphorus compounds.
| Molecular weight | 146.21 |
|---|---|
| Linear formula | (CH3)3CPHC(CH3)3 |
| Assay | 98% |
| Density | 0.79 g/mL at 25 °C(lit.) |
Hazard statements
- H225Highly flammable liquid and vapour
- H250Catches fire spontaneously if exposed to air
- H314Causes severe skin burns and eye damage
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P222Do not allow contact with air
- P231Handle under inert gas
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P422
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | -17 °C / 1.4 °F |
| Transport (UN / ADR) | UN 2845 4.2 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,C |
| Risk statements (R) | 17-34 |
| Safety statements (S) | 16-26-27-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Ligand For | Buchwald-Hartwig Cross Coupling ReactionHeck ReactionSuzuki-Miyaura Coupling |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Di-tert-butylphosphine used for?
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Di-tert-butylphosphine is primarily used as a ligand in various catalytic cross-coupling reactions, including Buchwald-Hartwig, Heck, and Suzuki-Miyaura couplings, as well as in general chemical synthesis.
What is the CAS number and formula for Di-tert-butylphosphine?
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The CAS number for Di-tert-butylphosphine is 819-19-2, and its linear formula is (CH3)3CPHC(CH3)3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Di-tert-butylphosphine with an assay of 98%. We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
How should Di-tert-butylphosphine be handled safely?
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Di-tert-butylphosphine is highly flammable and corrosive. Handle with extreme care in a well-ventilated area, using appropriate personal protective equipment including gloves, eye protection, and respiratory protection. It requires protection from air and moisture.
Is Di-tert-butylphosphine a controlled substance?
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The provided data does not indicate that Di-tert-butylphosphine is a controlled substance.
How is Di-tert-butylphosphine typically shipped and exported?
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Di-tert-butylphosphine is shipped under UN 2845, hazard class 4.2, as it is pyrophoric. Tech Serve Solutions exports chemicals globally, adhering to all relevant shipping and handling regulations.
How can I request a quote or sample of Di-tert-butylphosphine?
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To request a quote or sample, please contact our sales team through the website or by phone, providing the product name and CAS number.
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