(R)-2-[Bis(3,5-dimethylphenyl)methyl]pyrrolidine

CAS 948595-04-8C21H27NChemical Synthesis

(R)-2-[Bis(3,5-dimethylphenyl)methyl]pyrrolidine (CAS: 948595-04-8) is a chiral organic compound with the molecular formula C21H27N and a molecular weight of 293.45 g/mol. It is a valuable intermediate and catalyst in asymmetric synthesis. Its specific stereochemistry makes it useful in reactions requiring precise control over enantioselectivity, particularly in the development of complex organic molecules and pharmaceutical intermediates.

Synonyms: C21H27N

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(R)-2-[Bis(3,5-dimethylphenyl)methyl]pyrrolidine (C21H27N) — chemical structure, CAS 948595-04-8; Chemistry, fine chemical supplied by Tech Serve Solutions

Asymmetric SynthesisChemical SynthesisChiral CatalystsLigandsand ReagentsCycloaddition

01 /Applications

Asymmetric Synthesis

This compound serves as a chiral catalyst or ligand in asymmetric synthesis, enabling the selective formation of one enantiomer over the other in chemical reactions. This is critical for producing enantiomerically pure active pharmaceutical ingredients (APIs).

Organocatalysis

As a proline-based organocatalyst, it can be employed in various enantioselective transformations, offering metal-free catalytic routes. This is advantageous for green chemistry initiatives and for avoiding metal contamination in sensitive syntheses.

Chiral Ligand Development

It functions as a precursor or component in the design and synthesis of more complex chiral ligands. These ligands are crucial for transition metal-catalyzed asymmetric reactions.

Cycloaddition Reactions

The compound can be utilized to promote enantioselective cycloaddition reactions, leading to the formation of cyclic structures with high stereochemical control.

02 /Properties

Molecular weight	293.45
Empirical formula	C21H27N
Assay	≥98.0% (HPLC)
Optical purity	ee: ≥99.5% (HPLC)
Storage temperature	2-8°C
Melting point	97-101 °C

03 /Safety & handling

GHS hazard pictogram: Harmful / irritant (GHS07) — Harmful / irritant

Warning

Hazard statements

H302Harmful if swallowed

Protective equipment	dust mask type N95 (US), Eyeshields, Gloves
Water hazard class (WGK, DE)	3
Hazard codes (EU)	Xn
Risk statements (R)	22

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

948595-04-8

MDL number

MFCD09750442

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What are the primary applications of (R)-2-[Bis(3,5-dimethylphenyl)methyl]pyrrolidine?

(R)-2-[Bis(3,5-dimethylphenyl)methyl]pyrrolidine is primarily used in asymmetric synthesis, organocatalysis, and as a chiral ligand component for enantioselective reactions.

What is the CAS number and molecular formula for this compound?

The CAS number is 948595-04-8 and the molecular formula is C21H27N.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies (R)-2-[Bis(3,5-dimethylphenyl)methyl]pyrrolidine with an assay of ≥98.0% (HPLC) and an optical purity of ee: ≥99.5% (HPLC). TSS does not represent this product as USP, EP, or BP grade.

What are the safety and handling precautions for (R)-2-[Bis(3,5-dimethylphenyl)methyl]pyrrolidine?

This compound is classified as a Warning with hazard statement H302 (Harmful if swallowed). Recommended personal protective equipment includes a dust mask type N95 (US), eyeshields, and gloves. Handle in a well-ventilated area.

Is this chemical shipped or exported internationally?

Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, and can arrange for the shipment and export of (R)-2-[Bis(3,5-dimethylphenyl)methyl]pyrrolidine.

How can I request a quote or sample?

To request a quote or sample of (R)-2-[Bis(3,5-dimethylphenyl)methyl]pyrrolidine, please contact the Tech Serve Solutions sales team via our website or directly by phone.