(R)-2-{Bis[3,5-bis(trifluoromethyl)phenyl]methyl}pyrrolidine hydrochloride
(R)-2-{Bis[3,5-bis(trifluoromethyl)phenyl]methyl}pyrrolidine hydrochloride (CAS 1217463-08-5) is a proline-based organocatalyst with a molecular weight of 545.79. Its structure, featuring bulky trifluoromethylphenyl groups, makes it a valuable chiral auxiliary in asymmetric synthesis. This compound is primarily employed in chemical synthesis for achieving high enantioselectivity in various transformations. It is supplied by Tech Serve Solutions with an assay of ≥96.5% (HPLC).
- Synonyms
- C21H15F12N · HCl
![(R)-2-{Bis[3,5-bis(trifluoromethyl)phenyl]methyl}pyrrolidine hydrochloride (C21H15F12N · HCl) — chemical structure, CAS 1217463-08-5; Chemistry, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F1217463-08-5.png&w=3840&q=75)
Asymmetric Synthesis
This chiral catalyst is utilised to promote enantioselective reactions, enabling the synthesis of optically pure compounds. Its structural features facilitate stereochemical control in complex organic transformations.
Organocatalysis
As a proline-based organocatalyst, it participates directly in reaction mechanisms without the need for metal cofactors. This is advantageous for applications where metal contamination is a concern.
Chiral Ligand Development
The molecule can serve as a precursor or a component in the development of more complex chiral ligands for transition metal catalysis. Its pyrrolidine scaffold offers a versatile platform for modification.
Pharmaceutical Intermediate Synthesis
It can be employed in synthetic routes targeting chiral pharmaceutical intermediates, where precise stereochemical control is critical for biological activity and regulatory compliance.
| Molecular weight | 545.79 |
|---|---|
| Empirical formula | C21H15F12N · HCl |
| Assay | ≥96.5% (HPLC)97% |
| Optical purity | enantiomeric excess: ≥98.5% (HPLC) |
| Storage temperature | 2-8°C |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (R)-2-{Bis[3,5-bis(trifluoromethyl)phenyl]methyl}pyrrolidine hydrochloride used for?
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This compound is primarily used as a chiral catalyst in asymmetric synthesis and general chemical synthesis to achieve high enantioselectivity.
What is the CAS number and formula for (R)-2-{Bis[3,5-bis(trifluoromethyl)phenyl]methyl}pyrrolidine hydrochloride?
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The CAS number is 1217463-08-5 and the empirical formula (hill notation) is C21H15F12N · HCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this product with an assay of ≥96.5% (HPLC), and an enantiomeric excess of ≥98.5% (HPLC). TSS does not represent this product as USP, BP, EP, or other pharmacopoeia grades.
How should (R)-2-{Bis[3,5-bis(trifluoromethyl)phenyl]methyl}pyrrolidine hydrochloride be handled?
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Handle with appropriate personal protective equipment including a dust mask (type N95 US recommended), eyeshields, and gloves. Avoid breathing dust. Ensure adequate ventilation. Store at 2-8°C. This compound may cause skin, eye, and respiratory irritation (H315, H319, H335).
Is this chemical a controlled substance?
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There is no information in the provided data to indicate that this chemical is a controlled substance.
How is this chemical shipped and exported?
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Tech Serve Solutions is a global supplier and exporter of fine chemicals and laboratory reagents. Specific shipping and export details can be provided upon request.
How can I request a sample or quote?
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Please contact the Tech Serve Solutions sales team via our website or direct contact details to request a sample or a formal quotation.
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