(1R,2S)-(−)-Norephedrine
(1R,2S)-(−)-Norephedrine (CAS: 492-41-1) is a chiral alkaloid with the linear formula C6H5CH(OH)CH(CH3)NH2 and a molecular weight of 151.21 g/mol. This compound is valuable in asymmetric synthesis as a chiral auxiliary and in various chemical synthesis applications. It is known for its specific optical activity and is supplied with a high purity assay for research and development purposes.
- IUPAC
- (1R,2S)-2-Amino-1-phenyl-1-propanol,L-(−)-Norephedrine
- Synonyms
- (1R,2S)-2-Amino-1-phenyl-1-propanolL-(−)-Norephedrine
Chiral Auxiliary in Asymmetric Synthesis
The stereochemistry of (1R,2S)-(−)-Norephedrine makes it an effective chiral auxiliary, guiding stereoselective reactions and enabling the synthesis of enantiomerically pure compounds essential in pharmaceuticals and fine chemicals.
Intermediate in Chemical Synthesis
This compound serves as a key building block in the synthesis of more complex molecules. Its functional groups allow for diverse chemical transformations, making it versatile in organic synthesis pathways.
Research and Development
Utilised in academic and industrial research labs for exploring new synthetic methodologies, studying reaction mechanisms, and developing novel compounds with potential biological activity.
| Molecular weight | 151.21 |
|---|---|
| Linear formula | C6H5CH(OH)CH(CH3)NH2 |
| Assay | 99% |
| Optical activity | [α]20/D −41°, c = 7 in 1 M HCl |
| Storage temperature | 2-8°C |
| Melting point | 51-53 °C(lit.) |
Hazard statements
- H302Harmful if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Flash point | 113 °C / 235.4 °F |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22-36/37/38 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Gene Information | rat ... Adra1a(29412), Adra1b(24173), Adra1d(29413) |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (1R,2S)-(−)-Norephedrine primarily used for?
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(1R,2S)-(−)-Norephedrine is primarily used as a chiral auxiliary in asymmetric synthesis and as an intermediate in chemical synthesis for research and development purposes.
What is the CAS number and linear formula for (1R,2S)-(−)-Norephedrine?
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The CAS number for (1R,2S)-(−)-Norephedrine is 492-41-1, and its linear formula is C6H5CH(OH)CH(CH3)NH2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies (1R,2S)-(−)-Norephedrine with an assay of 99%. This product is intended for research and development purposes and is not represented as USP, BP, EP, or other pharmacopoeia grades.
What are the safety considerations when handling (1R,2S)-(−)-Norephedrine?
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When handling (1R,2S)-(−)-Norephedrine, it is important to use personal protective equipment including a dust mask (type N95 US), eyeshields, and gloves. The compound is classified as a Warning with hazards including H302 (Harmful if swallowed), H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation). Ensure adequate ventilation and avoid dust formation.
How is (1R,2S)-(−)-Norephedrine packed, shipped, and exported?
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Tech Serve Solutions ensures that (1R,2S)-(−)-Norephedrine is securely packed and adheres to all regulations for global shipping and export. Specific packaging details are provided upon request.
How can I request a sample or quote for (1R,2S)-(−)-Norephedrine?
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To request a sample or quote for (1R,2S)-(−)-Norephedrine, please contact our sales department through the website or by phone, providing your specific requirements.
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