Tetraethylene glycol p-toluenesulfonate
Tetraethylene glycol p-toluenesulfonate (CAS 77544-60-6), with the empirical formula C15H24O7S and a molecular weight of 348.41 g/mol, is a sulphur-containing organic building block. It serves as a versatile intermediate in chemical synthesis, particularly within organic chemistry research and development. Its tosylate group makes it a useful leaving group for various substitution reactions, enabling the introduction of the tetraethylene glycol chain into diverse molecular structures.
- IUPAC
- 2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]ethyl 4-methylbenzenesulfonate,2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]ethyl toluene-4-sulfonate,2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]ethyl toluenesulfonate,2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]ethyl tosylate,Monotosylated tetraethylene glycol,Tetraethylene glycol monotosylate
- Synonyms
- 2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]ethyl 4-methylbenzenesulfonate2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]ethyl toluene-4-sulfonate2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]ethyl toluenesulfonate2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]ethyl tosylateMonotosylated tetraethylene glycolTetraethylene glycol monotosylate

Organic Synthesis Intermediate
This compound is employed as a key intermediate in the synthesis of complex organic molecules. The tosylate moiety acts as an excellent leaving group, facilitating nucleophilic substitution reactions to form new carbon-heteroatom or carbon-carbon bonds.
Building Block for Polyethers
Its structure, based on tetraethylene glycol, makes it suitable for incorporation into polymers or functional materials where specific chain lengths and ether linkages are desired. This can be useful in the development of specialized materials or drug delivery systems.
Research and Development
Used in academic and industrial research laboratories for exploring novel synthetic pathways and creating new chemical entities. It enables chemists to access diverse molecular architectures by functionalising the tetraethylene glycol chain.
| Molecular weight | 348.41 |
|---|---|
| Empirical formula | C15H24O7S |
| Assay | 97% |
| Density | 1.202 g/mL at 25 °C |
| Refractive index | n20/D 1.507 |
| Storage temperature | 2-8°C |


Hazard statements
- H301Toxic if swallowed
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P301IF SWALLOWED
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Flash point | >110 °C / >230 °F |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T,Xi |
| Risk statements (R) | 25-34-36 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Tetraethylene glycol p-toluenesulfonate used for?
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Tetraethylene glycol p-toluenesulfonate is primarily used as an intermediate in organic synthesis and as a building block in research and development for creating complex molecules and specialized materials.
What is the CAS number and formula for Tetraethylene glycol p-toluenesulfonate?
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The CAS number is 77544-60-6 and the empirical formula is C15H24O7S.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Tetraethylene glycol p-toluenesulfonate with an assay of 97%. We do not represent this product as USP, BP, or EP grade.
How should Tetraethylene glycol p-toluenesulfonate be handled safely?
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This compound is classified as Dangerous. It causes severe skin burns and eye damage (H314) and is toxic if swallowed (H301). Handle with appropriate personal protective equipment, including gloves, eye protection, and protective clothing, in a well-ventilated area. Avoid ingestion and contact with skin and eyes.
Is Tetraethylene glycol p-toluenesulfonate available for export?
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Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, including Tetraethylene glycol p-toluenesulfonate.
How can I request a quote or sample?
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To request a quote or sample of Tetraethylene glycol p-toluenesulfonate, please contact our sales team through our website or by phone.
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