Tetraethylene glycol dimethyl ether
Tetraethylene glycol dimethyl ether (CAS: 143-24-8), with the chemical formula CH3O(CH2CH2O)4CH3, is a high-boiling, stable polar aprotic solvent. It is a clear, colourless liquid with a molecular weight of 222.28 g/mol. This compound serves as a valuable building block in organic synthesis and finds applications as a reaction medium or solvent in various chemical processes, particularly where high temperatures or specific solvation properties are required.
- IUPAC
- 2,5,8,11,14-Pentaoxapentadecane,Bis[2-(2-methoxyethoxy)ethyl] ether,Dimethoxytetraethylene glycol,Dimethyltetraglycol,Tetraglyme
- Synonyms
- 2,5,8,11,14-PentaoxapentadecaneBis[2-(2-methoxyethoxy)ethyl] etherDimethoxytetraethylene glycolDimethyltetraglycolTetraglyme

Solvent for Organic Reactions
Tetraethylene glycol dimethyl ether is an effective polar aprotic solvent for various organic reactions, including organometallic chemistry and reductions. Its high boiling point allows for reactions to be conducted at elevated temperatures.
Reaction Medium
It functions as a versatile reaction medium in processes requiring a solvent with excellent thermal stability and good solvating power for both organic and inorganic reagents.
Chemical Synthesis
As an organic building block, it can be utilised in the synthesis of more complex molecules. Its ether linkages provide specific chemical properties useful in multi-step syntheses.
High-Temperature Applications
The compound's high boiling point and stability make it suitable for applications requiring consistent performance at elevated temperatures, without significant solvent loss or degradation.
| Molecular weight | 222.28 |
|---|---|
| Linear formula | CH3O(CH2CH2O)4CH3 |
| Assay | ≥98.0% (GC) |
| Grade | purum |
| Boiling point | 275-276 °C(lit.) |
| Density | 1.009 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.432(lit.)n20/D 1.432 |
| Melting point | −30 °C(lit.) |
| Vapour pressure | <0.01 mmHg (20 °C) |
| Vapour density | 7.7 (vs air) |
| Autoignition temp | 510 °F |
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 141 °C / 285.8 °F |
| Water hazard class (WGK, DE) | 1 |
| Risk statements (R) | 19 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Tetraethylene glycol dimethyl ether used for?
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Tetraethylene glycol dimethyl ether is used as a solvent for organic reactions, a reaction medium, and a building block in chemical synthesis, particularly in high-temperature applications.
What are the CAS number and chemical formula for Tetraethylene glycol dimethyl ether?
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The CAS number is 143-24-8, and the chemical formula is CH3O(CH2CH2O)4CH3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Tetraethylene glycol dimethyl ether at a 'purum' grade with an assay of ≥98.0% (GC). We do not represent this product as USP, BP, or EP grade.
How should Tetraethylene glycol dimethyl ether be handled safely?
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Handling requires appropriate personal protective equipment, including eyeshields, faceshields, and gloves. A multi-purpose respirator cartridge or an ABEK respirator filter is recommended for respiratory protection. Always consult the Safety Data Sheet for detailed handling information.
Is Tetraethylene glycol dimethyl ether a controlled substance?
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Based on the provided data, there is no indication that Tetraethylene glycol dimethyl ether is a controlled substance.
How is Tetraethylene glycol dimethyl ether packed and exported?
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Tetraethylene glycol dimethyl ether is packed and exported by Tech Serve Solutions in compliance with international shipping regulations for chemicals.
How can I request a quote or sample of Tetraethylene glycol dimethyl ether?
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To request a quote or a sample of Tetraethylene glycol dimethyl ether, please contact our sales team through the website or by phone.
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