1-(2-Hydroxyphenyl)piperazine
1-(2-Hydroxyphenyl)piperazine (CAS 1011-17-2; C10H14N2O; molar mass 178.23 g/mol) is a heterocyclic building block in which a piperazine ring is N-linked to the 2-position of phenol. Also known as 2-(1-piperazino)phenol, it is a solid melting at about 125-129 degrees C and is supplied at 97% assay. Tech Serve Solutions offers it as a research-grade synthetic intermediate for pharmaceutical and fine-chemical discovery, where its bifunctional amine and phenol groups support onward derivatisation.
- IUPAC
- 2-(1-Piperazino)phenol
- Synonyms
- 1-(2-Hydroxyphenyl)piperazine2-(1-Piperazino)phenol2-(Piperazin-1-yl)phenol1-(2-Hydroxyphenyl)piperazine, CAS 1011-17-2
Pharmaceutical intermediate
Serves as a building block in medicinal chemistry and the synthesis of pharmaceutical candidates. The substituted piperazine scaffold is a recurring motif in active pharmaceutical ingredient research.
Heterocyclic building block
Used in chemical synthesis to introduce a 2-hydroxyphenyl-piperazine unit into larger molecules. The secondary amine of the piperazine ring is a convenient site for alkylation, acylation and reductive amination.
Bifunctional coupling reagent
The adjacent phenolic hydroxyl and the piperazine nitrogen provide two complementary reactive handles, enabling ether or ester formation at oxygen and amide or amine chemistry at nitrogen for the construction of more complex structures.
Ligand and coordination chemistry
The combination of a phenol oxygen donor with piperazine nitrogen donors makes the compound of interest as a precursor to chelating ligands in coordination and materials research. Specific applications should be confirmed for the intended use.
| Molecular weight | 178.23 |
|---|---|
| Empirical formula | C10H14N2O |
| Assay | 97% |
| Melting point | 125-129 °C |
Hazard statements
- H301Toxic if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P301IF SWALLOWED
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 2811 6.1 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T |
| Risk statements (R) | 25-36/37/38 |
| Safety statements (S) | 26-37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1-(2-Hydroxyphenyl)piperazine used for?
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It is used primarily as a heterocyclic building block and synthetic intermediate in pharmaceutical and fine-chemical research. The piperazine and phenol functionalities allow it to be elaborated into more complex molecules during medicinal-chemistry and discovery work.
What is the CAS number and molecular formula of 1-(2-Hydroxyphenyl)piperazine?
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The CAS number is 1011-17-2 and the molecular formula is C10H14N2O, with a molecular weight of 178.23 g/mol. Its MDL number is MFCD00190246 and its EC number is 213-782-5.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 1-(2-Hydroxyphenyl)piperazine at a typical assay of 97% as a research and synthesis-grade material. We do not represent it as USP, BP or EP pharmacopoeial grade. A certificate of analysis is provided with each batch.
What are the safety and handling requirements for 1-(2-Hydroxyphenyl)piperazine?
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The compound is classified under GHS with signal word Danger (pictograms GHS06 and GHS07). It is toxic if swallowed (H301), causes skin irritation (H315) and serious eye irritation (H319), and may cause respiratory irritation (H335). Handle with eye and face protection, gloves and suitable respiratory protection (type P2 cartridges), avoid dust and vapour, and consult the SDS before use.
How is 1-(2-Hydroxyphenyl)piperazine packed, shipped and exported?
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It is packed in sealed, appropriately labelled containers sized to order and shipped with full documentation. For transport it is classified as UN 2811, Class 6.1, Packing Group III; consignments are prepared and declared to applicable ADR, IMDG and IATA dangerous-goods rules for export worldwide.
How do I request a sample or quote?
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Contact Tech Serve Solutions with your required quantity, grade and destination, and our team will respond with availability, lead time and documentation. Samples and bulk quantities can be arranged for qualified laboratory and industrial customers.
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