1-(2-Mesitylenesulfonyl)-3-nitro-1H-1,2,4-triazole
1-(2-Mesitylenesulfonyl)-3-nitro-1H-1,2,4-triazole (CAS 74257-00-4), commonly abbreviated MSNT, is a crystalline triazolide condensing reagent with the molecular formula C11H12N4O4S and a molar mass of 296.30 g/mol. It activates carboxylic acids, phosphates and related substrates toward esterification and coupling, and is best known as a condensing reagent in oligonucleotide synthesis. Tech Serve Solutions supplies it as a research-grade reagent to laboratories and manufacturers worldwide.
- IUPAC
- (2,4,6-Trimethylphenyl)-(3-nitro-1,2,4-triazol-1-yl) sulfone,MSNT
- Synonyms
- 1-(2-Mesitylenesulfonyl)-3-nitro-1H-1,2,4-triazoleMSNT(2,4,6-Trimethylphenyl)-(3-nitro-1,2,4-triazol-1-yl) sulfone1-(Mesitylene-2-sulfonyl)-3-nitro-1,2,4-triazole3-Nitro-1-(2,4,6-trimethylbenzenesulfonyl)-1,2,4-triazoleCAS 74257-00-4
Oligonucleotide synthesis
MSNT is employed as a condensing reagent in oligonucleotide synthesis, activating the internucleotide coupling step. It is a long-established reagent in phosphotriester approaches to nucleic acid assembly.
Esterification and macrolactonisation
The reagent activates carboxylic acids toward ester bond formation under mild conditions. It is widely used for the esterification of sterically demanding or sensitive substrates, including intramolecular lactonisation in total synthesis.
Coupling and condensation chemistry
As a sulfonyl-triazole condensing agent, MSNT promotes the union of acidic and nucleophilic partners. It serves as a general activating reagent in chemical synthesis where a reactive acyl or phosphoryl intermediate is required.
Peptide and solid-phase chemistry
MSNT is used in peptide chemistry and solid-phase work, for example in the attachment of the first amino acid residue to hydroxyl-functionalised resins. Its activation profile suits demanding esterification steps in chain assembly.
| Molecular weight | 296.30 |
|---|---|
| Empirical formula | C11H12N4O4S |
| Storage temperature | −20°C |
| Application | Condensing reagent for oligonucleotide synthesis. |
| Melting point | 134-139 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1-(2-Mesitylenesulfonyl)-3-nitro-1H-1,2,4-triazole used for?
+
It is used as a condensing reagent. Its principal application is in oligonucleotide synthesis, where it activates the coupling step, and it is also a versatile reagent for esterification, macrolactonisation and related condensation reactions in chemical and peptide synthesis.
What is the CAS number and molecular formula of 1-(2-Mesitylenesulfonyl)-3-nitro-1H-1,2,4-triazole?
+
The CAS number is 74257-00-4 and the molecular formula is C11H12N4O4S, with a molecular weight of 296.30 g/mol. It is also catalogued under MDL number MFCD00009754 and Beilstein registry number 4328921, and is widely abbreviated as MSNT.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies this compound as a research-grade reagent suitable for synthetic chemistry, with a reported melting point of 134-139 degC. We do not represent it as USP, BP or EP pharmacopoeia grade. Specifications and a certificate of analysis are confirmed at the time of quotation.
What are the safety and handling requirements for this reagent?
+
The compound carries GHS07 with the signal word Warning and hazard statements H315 (causes skin irritation), H319 (causes serious eye irritation) and H335 (may cause respiratory irritation). Handle with gloves, eye protection and an N95-type dust mask, avoid dust formation, and follow P261 and P305+P351+P338. It is assigned WGK 3 (water-hazard) in Germany. Recommended storage is at -20 degC.
How is 1-(2-Mesitylenesulfonyl)-3-nitro-1H-1,2,4-triazole packed, shipped and exported?
+
The reagent is packed in tightly sealed, moisture-protected containers appropriate to the order quantity and labelled to GHS requirements. Tech Serve Solutions exports globally with the relevant documentation, including the SDS and certificate of analysis, and observes recommended cold storage handling during transit.
How do I request a sample or quote?
+
Contact Tech Serve Solutions with your required quantity, packing and destination, and our team will confirm availability, current specifications and lead time. Samples may be arranged subject to availability.
▶ Related products
1-(2-Fluorobenzyl)piperazine
C11H15FN2
Chemical Synthesis
1-(2-Fluorophenyl)biguanide hydrochloride
Chemical Synthesis
1-(2-Fluorophenyl)cyclopropanecarboxylic acid
C10H9FO2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine
C10H13FN2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine monohydrochloride
C10H13FN2 · HCl
Chemical Synthesis
1-(2-Furoyl)-1H-benzotriazole
C11H7N3O2
Chemical Synthesis
1-(2-Furoyl)piperazine
C9H12N2O2
Chemical Synthesis
1-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione
Chemical Synthesis
▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis