Tris(2,6-dimethoxyphenyl)phosphine
Tris(2,6-dimethoxyphenyl)phosphine (CAS: 85417-41-0) is a highly substituted phosphine ligand with the molecular formula [(CH3O)2C6H3]3P and a molecular weight of 442.44 g/mol. This compound functions as an effective catalyst in various organic transformations, including cross-coupling reactions, heterocycle synthesis, and enantioselective aldol reactions. It is supplied by Tech Serve Solutions with a purity of 98%.
- IUPAC
- DMPP
- Synonyms
- [(CH3O)2C6H3]3P
![Tris(2,6-dimethoxyphenyl)phosphine ([(CH3O)2C6H3]3P) — chemical structure, CAS 85417-41-0; Chemistry, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F85417-41-0.png&w=3840&q=75)
Catalysis in Organic Synthesis
This phosphine ligand is employed as a catalyst in diverse synthetic methodologies. It facilitates the preparation of chiral building blocks via hydroalkynylation and is crucial for atom-economic synthesis of nitrogen heterocycles and ynenoates from alkynes.
Cross-Coupling Reactions
Tris(2,6-dimethoxyphenyl)phosphine serves as a ligand in Palladium-mediated cross-coupling reactions. It is also utilized in copper-mediated dimerization and benzannulation reactions, highlighting its versatility in C-C and C-heteroatom bond formation.
Chiral Chemistry and Asymmetric Synthesis
The compound is instrumental in creating chiral molecules, notably through its application in enantioselective aldol reactions and the preparation of chiral building blocks. It also catalyses three-component aza-Morita-Baylis-Hillman reactions.
Heterocycle and Ynenoate Synthesis
It enables the atom-economic synthesis of nitrogen heterocycles and ynenoates when starting from alkynes. Furthermore, it is involved in the oxycyclizations of allendiols, expanding its utility in complex molecule construction.
| Molecular weight | 442.44 |
|---|---|
| Linear formula | [(CH3O)2C6H3]3P |
| Assay | 98% |
| Application | Catalyst for:• Preparation of chiral building blocks via hydroalkynylation reactions or ynolates1• Three-component aza-Morita-Baylis-Hillman reactions (aza-MBH)2• Atom-economic synthesis of nitrogen heterocycles and ynenoates from alkynes3• Oxycylizations of allendiols4• Enantioselective aldol reactions5• Pd-mediated cross-coupling, Pd- and Cu-mediated benzannulation reactions and copper-mediated dimerization reactions6 |
| Melting point | 145-147 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Tris(2,6-dimethoxyphenyl)phosphine used for?
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Tris(2,6-dimethoxyphenyl)phosphine is primarily used as a ligand in various catalytic processes, including cross-coupling reactions, enantioselective synthesis, heterocycle formation, and the preparation of chiral building blocks.
What are the CAS number and molecular formula for Tris(2,6-dimethoxyphenyl)phosphine?
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The CAS number is 85417-41-0, and the linear molecular formula is [(CH3O)2C6H3]3P.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Tris(2,6-dimethoxyphenyl)phosphine at a minimum purity of 98%. We do not represent this product as USP, BP, or EP grade.
How should Tris(2,6-dimethoxyphenyl)phosphine be handled safely?
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This compound is classified as an irritant. Handle with appropriate personal protective equipment, including a dust mask (type N95 US), eyeshields, and gloves. Ensure good ventilation and avoid breathing dust. In case of contact, follow standard first-aid procedures as indicated by the hazard statements (H315, H319, H335).
Is Tris(2,6-dimethoxyphenyl)phosphine available for export?
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Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals and laboratory reagents.
How can I request a quote or sample for Tris(2,6-dimethoxyphenyl)phosphine?
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To request a quote or sample, please contact our sales team through the website or by phone, providing the product name and CAS number (85417-41-0).
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