Trimethyl orthopropionate
Trimethyl orthopropionate (CAS 24823-81-2), with the linear formula CH3CH2C(OCH3)3 and a molecular weight of 134.17 g/mol, is a versatile organic compound. It belongs to the class of orthoesters and serves as a valuable building block in organic synthesis. Its chemical properties make it suitable for various transformations in the development of complex molecules.
- IUPAC
- 1,1,1-Trimethoxypropane
- Synonyms
- 1,1,1-Trimethoxypropane

Organic Synthesis Reagent
Trimethyl orthopropionate is utilised as a reagent in organic synthesis, particularly for the introduction of protected carbonyl functionalities or for the formation of acetals and ketals. It can participate in reactions requiring its specific orthoester structure.
Chemical Intermediate
This compound acts as a chemical intermediate in the production of more complex organic molecules. Its functional groups allow for further chemical modification and incorporation into larger structures within multi-step syntheses.
Building Block for Fine Chemicals
As an organic building block, Trimethyl orthopropionate finds application in the fine chemical industry. It contributes to the synthesis of specialised chemicals where its unique structure is advantageous.
| Molecular weight | 134.17 |
|---|---|
| Linear formula | CH3CH2C(OCH3)3 |
| Assay | ≥95.0% (T) |
| Boiling point | 121-122 °C(lit.) |
| Density | 0.944 g/mL at 20 °C(lit.) |
| Refractive index | n20/D 1.398 |


Hazard statements
- H225Highly flammable liquid and vapour
- H315Causes skin irritation
- H319Causes serious eye irritation
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 19 °C / 66.2 °F |
| Transport (UN / ADR) | UN 3272 3 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,Xi |
| Risk statements (R) | 11-36/38 |
| Safety statements (S) | 16-26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Trimethyl orthopropionate used for?
+
Trimethyl orthopropionate (CAS 24823-81-2) is used as a reagent in organic synthesis and as a chemical intermediate for producing more complex organic molecules and fine chemicals.
What are the CAS number and molecular formula for Trimethyl orthopropionate?
+
The CAS number for Trimethyl orthopropionate is 24823-81-2, and its linear formula is CH3CH2C(OCH3)3.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies Trimethyl orthopropionate with an assay of ≥95.0% (T). TSS does not represent this product as USP, BP, EP, or other pharmacopoeia grades.
What are the primary safety concerns when handling Trimethyl orthopropionate?
+
Trimethyl orthopropionate is a flammable liquid and irritant. It carries GHS hazard statements H225 (Highly flammable liquid and vapour) and H315-H319 (Causes skin and serious eye irritation). Always use appropriate personal protective equipment, including eyeshields and gloves, and handle in a well-ventilated area away from ignition sources.
How is Trimethyl orthopropionate packed, shipped, and exported?
+
Tech Serve Solutions can pack, ship, and export Trimethyl orthopropionate according to international shipping regulations (UN 3272, Class 3, PG II). Please contact us for specific export requirements and logistics.
How can I request a quote or sample for Trimethyl orthopropionate?
+
To request a quote or a sample of Trimethyl orthopropionate, please use the contact form on our website or call our sales team. Please specify the required quantity and your shipping destination.
▶ Related products

1-(2-Fluorobenzyl)piperazine
C11H15FN2
Chemical Synthesis
1-(2-Fluorophenyl)biguanide hydrochloride
Chemical Synthesis

1-(2-Fluorophenyl)cyclopropanecarboxylic acid
C10H9FO2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine
C10H13FN2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine monohydrochloride
C10H13FN2 · HCl
Chemical Synthesis
1-(2-Furoyl)-1H-benzotriazole
C11H7N3O2
Chemical Synthesis
1-(2-Furoyl)piperazine
C9H12N2O2
Chemical Synthesis
1-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione
Chemical Synthesis
▶ Explore more

3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis

3-Methyl-1,5-pentanediol
Chemical Synthesis

3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis