Trimethyl orthobutyrate
Trimethyl orthobutyrate (CAS: 43083-12-1; Formula: C7H16O3; Molar Mass: 148.20 g/mol) is an organic ortho ester. It is a versatile chemical building block utilized in various organic synthesis applications. Its unique structure allows it to serve as a precursor and intermediate in the production of more complex molecules, particularly within the pharmaceutical and fine chemical industries. The compound offers distinct reactivity for introducing specific functionalities in chemical transformations.
- IUPAC
- 1,1,1-Trimethoxybutane
- Synonyms
- 1,1,1-Trimethoxybutane
Organic Synthesis
Trimethyl orthobutyrate serves as a valuable reagent in organic synthesis. It can be employed as a protecting group or as a source of the butyryl moiety in various chemical reactions. Its reactivity profile makes it suitable for constructing complex organic molecules.
Pharmaceutical Intermediates
This compound can function as an intermediate in the synthesis of active pharmaceutical ingredients (APIs) and related compounds. Its structural features can be incorporated into drug candidates or used in the process of their manufacture.
Building Block Chemistry
As a readily available building block, Trimethyl orthobutyrate facilitates the creation of diverse chemical structures. It is particularly useful for introducing a protected carbonyl group or a specific carbon chain into target molecules.
| Molecular weight | 148.20 |
|---|---|
| Linear formula | CH3CH2CH2C(OCH3)3 |
| Assay | ≥97.0% (GC) |
| Boiling point | 145-147 °C(lit.) |
| Density | 0.926 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.404(lit.)n20/D 1.404 |
Hazard statements
- H226Flammable liquid and vapour
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 50 °C / 122 °F |
| Transport (UN / ADR) | UN 3272 3 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 10-36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Trimethyl orthobutyrate used for?
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Trimethyl orthobutyrate is primarily used as a building block in organic synthesis and as an intermediate in the production of pharmaceutical compounds and other fine chemicals.
What are the CAS number and formula for Trimethyl orthobutyrate?
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The CAS number is 43083-12-1 and the molecular formula is C7H16O3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Trimethyl orthobutyrate with an assay of ≥97.0% (GC). TSS does not represent this product as USP, EP, BP, or any other pharmacopoeia grade.
What are the safety considerations for handling Trimethyl orthobutyrate?
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Trimethyl orthobutyrate is classified as a flammable liquid and irritant. It causes skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335). Handling requires appropriate personal protective equipment, including eyeshields, gloves, and suitable respiratory protection in a well-ventilated area. It has a flash point of 50 °C (122 °F).
How is Trimethyl orthobutyrate packed and shipped?
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Trimethyl orthobutyrate is packed and shipped according to international regulations for hazardous materials, including UN 3272, Class 3, Packing Group III. For export, please consult our shipping department for specific requirements.
How can I request a sample or a quote for Trimethyl orthobutyrate?
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To request a sample or a quote, please use the online form on our website or contact our sales team directly. Please specify the quantity required and your delivery location.
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