Tolazamide
Tolazamide (CAS: 1156-19-0) is a chemical compound with the molecular formula C14H21N3O3S and a molecular weight of 311.40 g/mol. Primarily recognised for its role as a K<sub>ATP</sub> channel inhibitor, Tolazamide is utilised in research settings to investigate its effects on physiological parameters such as mean arterial blood pressure. Its utility extends to studies within cell biology and neuroscience, focusing on ion channel modulation.
- IUPAC
- 1-(Hexahydro-1H-azepin-1-yl)-3-(p-toluenesulfonyl)urea
K<sub>ATP</sub> Channel Inhibition
Tolazamide serves as a potassium channel ATP-sensitive (K<sub>ATP</sub>) inhibitor. It has been employed in preclinical research to study its impact on mean arterial blood pressure in animal models, specifically in the context of hemorrhagic shock.
Research in Physiology
This compound is valuable for researchers investigating the physiological roles of K<sub>ATP</sub> channels. Studies may focus on its effects on cardiovascular parameters and its potential implications in various shock states.
Cellular and Neuroscience Research
As a bioactive small molecule, Tolazamide finds applications in cell biology and neuroscience research, particularly concerning cell signaling pathways and the function of ion channels.
| Molecular weight | 311.40 |
|---|---|
| Empirical formula | C14H21N3O3S |
| Solubility | 0.1 M NaOH: soluble4.3 mg/ml45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: soluble2.7 mg/mlDMSO: soluble32.5 mg/mlacetone: soluble50 mg/ml, clear, colorless to light yellow |
| Application | Tolazamide has been used as a KATP channel inhibitor to study changes in mean arterial blood pressure (MAP) in rat models of severe hemorrhagic shock2. |
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Gene Information | human ... ALB(213), KCNJ1(3758) |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Tolazamide used for?
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Tolazamide is used as a K<sub>ATP</sub> channel inhibitor in research to study its effects on mean arterial blood pressure and in cell biology and neuroscience research.
What is the CAS number and formula for Tolazamide?
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The CAS number for Tolazamide is 1156-19-0, and its empirical formula is C14H21N3O3S.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Tolazamide at research grade. We do not represent it as USP, BP, EP or for human consumption. Please refer to the product specifications for lot-specific assay details.
What are the safety and handling precautions for Tolazamide?
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Handle Tolazamide with appropriate personal protective equipment, including a type N95 dust mask, eyeshields, and gloves. Refer to the safety data sheet for comprehensive hazard information. Its WGK Germany is 3.
How is Tolazamide packed, shipped, and exported?
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Tolazamide is carefully packed to ensure safe transit and is available for export globally by Tech Serve Solutions.
How can I request a sample or quote for Tolazamide?
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To request a sample or a quotation for Tolazamide, please contact our sales department via the website or by phone.
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