Tolcapone

CAS 134308-13-7C14H11NO5Cell Biology

Tolcapone (CAS 134308-13-7), with the molecular formula C14H11NO5 and a molecular weight of 273.24 g/mol, is a yellow powder. This compound functions as a catechol-O-methyltransferase (COMT) inhibitor. It is valuable in research settings for studying COMT-mediated cell signaling pathways and neurotransmitter metabolism. Tolcapone is supplied by Tech Serve Solutions for research and development purposes.

IUPAC: 3,4-Dihydroxy-4′-methyl-5-nitrobenzophenone,Ro 40-7592
Synonyms: 3,4-Dihydroxy-4′-methyl-5-nitrobenzophenoneRo 40-7592

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Tolcapone (C14H11NO5) — chemical structure, CAS 134308-13-7; Life Science, fine chemical supplied by Tech Serve Solutions

Bioactive Small MoleculesCatechol-O-methyltransferaseCell BiologyEnzyme InhibitorsNeuroscienceNeurotransmissionNeurotransmitter MetabolismRocheT More...

01 /Applications

COMT Inhibition Studies

Tolcapone is utilized as a selective inhibitor of catechol-O-methyltransferase (COMT). This makes it a valuable tool for researchers investigating the role of COMT in catecholamine metabolism and signaling pathways.

Neuroscience Research

Given its impact on neurotransmitter metabolism, Tolcapone is employed in neuroscience research to explore the modulation of dopaminergic and other catecholaminergic systems.

Cell Signaling Investigations

This compound is used in studies focused on cell signaling, particularly where COMT activity influences cellular responses or the availability of signaling molecules.

02 /Properties

Molecular weight	273.24
Empirical formula	C14H11NO5
Assay	≥98% (HPLC)
Form	powder
Colour	yellow
Solubility	DMSO: ≥15 mg/mL
Storage temperature	2-8°C
Application	Tolcapone may be used in COMT-mediated cell signaling studies.

03 /Safety & handling

GHS hazard pictogram: Environmental hazard (GHS09) — Environmental hazard

Warning

Hazard statements

H400Very toxic to aquatic life

Precautionary statements

P273Avoid release to the environment

Transport (UN / ADR)	UN 3077 9 / PGIII
Hazard codes (EU)	N
Risk statements (R)	50
Safety statements (S)	61

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

134308-13-7

05 /Additional specifications

Storage Condition	desiccated

06 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

07 /Frequently asked questions

What is Tolcapone used for?

Tolcapone is used for COMT-mediated cell signaling studies and in neuroscience research to investigate the modulation of catecholaminergic systems.

What is the CAS number and formula for Tolcapone?

The CAS number for Tolcapone is 134308-13-7, and its empirical formula (Hill notation) is C14H11NO5.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies Tolcapone with an assay of ≥98% (HPLC). We do not represent this product as USP, BP, or EP grade.

How should Tolcapone be handled and stored?

Tolcapone is classified under GHS09 with the signal word Warning, indicating it is very toxic to aquatic life (H400). It should be handled with care, avoiding release into the environment (P273). Store desiccated at 2-8°C.

How is Tolcapone packed and exported?

Tolcapone is supplied as a yellow powder and is typically stored refrigerated. We export chemicals globally, adhering to all relevant shipping regulations, including UN 3077 for transport.