Tofacitinib citrate
Tofacitinib citrate (CAS 540737-29-9) is a highly pure white to beige powder with the empirical formula C16H20N6O · C6H8O7 and a molecular weight of 504.49 g/mol. This compound functions as a potent inhibitor of Janus Kinase (JAK) pathways. It is widely used in biochemical research and drug discovery for investigating cell signaling, immune responses, and inflammatory conditions. Its specific action on JAK enzymes makes it a valuable tool for studying cellular communication and disease mechanisms.
- IUPAC
- (3R,4R)-4-Methyl-3-(methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-β-oxo-1-piperidinepropanenitrile citrate salt,3-[(3R,4R)-4-Methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl]-3-oxopropanenitrile citrate salt,CP-690550-10,Tasocitinib citrate salt
- Synonyms
- 3-[(3R,4R)-4-Methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl]-3-oxopropanenitrile citrate saltCP-690550-10Tasocitinib citrate salt(3R,4R)-4-Methyl-3-(methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-β-oxo-1-piperidinepropanenitrile citrate salt
Janus Kinase (JAK) Inhibition Studies
Tofacitinib citrate is employed as a research tool to selectively inhibit Janus Kinase (JAK) enzymes. This allows scientists to investigate the roles of JAK-STAT signaling pathways in cellular processes, immune function, and the pathogenesis of various diseases.
Cellular Signalling Research
Utilised in cell biology laboratories to probe complex intracellular signalling cascades. Researchers use it to understand how blocking JAK activity impacts gene expression, cell differentiation, and immune cell activation.
Drug Discovery and Development
Serves as a reference compound and research probe in the development of novel therapeutics targeting inflammatory and autoimmune diseases. Its mechanism of action provides insights for designing new kinase inhibitors.
Neuroscience Research
Investigated for its potential roles in neurological processes and disorders where JAK signalling may be implicated. It aids in understanding the neuro-inflammatory aspects of certain central nervous system conditions.
| Molecular weight | 504.49 |
|---|---|
| Empirical formula | C16H20N6O · C6H8O7 |
| Assay | ≥98% (HPLC) |
| Form | powder |
| Colour | white to beige |
| Solubility | DMSO: soluble5 mg/mL (clear solution; warmed) |
| Storage temperature | room temp |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Tofacitinib citrate primarily used for in research?
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Tofacitinib citrate is primarily used as a research chemical to inhibit Janus Kinase (JAK) enzymes, enabling studies into cell signaling pathways, immune responses, and inflammatory conditions.
What is the CAS number and formula for Tofacitinib citrate?
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The CAS number for Tofacitinib citrate is 540737-29-9, and its empirical formula is C16H20N6O · C6H8O7.
What grade and purity does Tech Serve Solutions supply for Tofacitinib citrate?
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Tech Serve Solutions supplies Tofacitinib citrate with a purity of ≥98% (HPLC). This product is intended for research purposes and is not supplied as USP, BP, or EP grade.
What are the safety considerations for handling Tofacitinib citrate?
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Tofacitinib citrate is classified under WGK Germany 3, indicating it is hazardous to water. Appropriate personal protective equipment, including gloves and eye protection, should be used, and handling should occur in a well-ventilated area or fume hood to avoid inhalation and contact.
How is Tofacitinib citrate typically packed and shipped?
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Tofacitinib citrate is supplied as a white to beige powder. It is typically packed securely to maintain its integrity during transport and exported globally following all relevant regulations.
How can I request a sample or quote for Tofacitinib citrate?
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To request a sample or obtain a quote for Tofacitinib citrate, please contact our sales team through the website or by phone with your specific requirements.
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