2-(Difluoromethoxy)phenyl isothiocyanate
2-(Difluoromethoxy)phenyl isothiocyanate (CAS: 101856-90-0) is a fluorinated organic compound with the linear formula F₂CHO C₆H₄NCS and a molecular weight of 201.19 g/mol. This chemical serves as a valuable building block in organic synthesis. Its isothiocyanate functionality makes it reactive in various chemical transformations, particularly for introducing the 2-(difluoromethoxy)phenyl moiety into larger molecular structures for research and development purposes.
Organic Synthesis Reagent
Utilised as a key intermediate in the synthesis of more complex organic molecules. Its reactive isothiocyanate group allows for facile derivatisation in heterocyclic chemistry and the formation of thiourea compounds.
Building Block for Medicinal Chemistry
Incorporated into the development of novel pharmaceutical candidates. The difluoromethoxy group can modulate lipophilicity and metabolic stability, making it an attractive feature in drug discovery programmes.
Research Chemical
A specialised reagent for academic and industrial research laboratories exploring new synthetic pathways and functional group transformations. Useful in the creation of diverse chemical libraries.
| Molecular weight | 201.19 |
|---|---|
| Linear formula | F2CHOC6H4NCS |
| Assay | 96% |
| Boiling point | 245-249 °C(lit.) |
| Density | 1.32 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.582(lit.) |
Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 110 °C / 230 °F |
| Transport (UN / ADR) | UN 1760 8 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34 |
| Safety statements (S) | 26-27-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-(Difluoromethoxy)phenyl isothiocyanate used for?
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This compound is primarily used as a building block and reagent in organic synthesis, particularly in medicinal chemistry research for the development of novel pharmaceutical candidates and in creating diverse chemical libraries.
What are the CAS number and formula for 2-(Difluoromethoxy)phenyl isothiocyanate?
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The CAS number is 101856-90-0, and the linear formula is F₂CHO C₆H₄NCS.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2-(Difluoromethoxy)phenyl isothiocyanate with a minimum assay of 96%. We do not represent this product as USP, BP, or EP grade.
How should 2-(Difluoromethoxy)phenyl isothiocyanate be handled safely?
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This compound is classified as Dangerous (GHS05, Signal Word: Danger) and causes severe skin burns and eye damage (H314). Handle with extreme caution, using appropriate personal protective equipment including faceshields, gloves, goggles, and a suitable respirator. Ensure good ventilation.
Is 2-(Difluoromethoxy)phenyl isothiocyanate packed and shipped internationally?
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Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, including 2-(Difluoromethoxy)phenyl isothiocyanate, adhering to all relevant shipping regulations.
How can I request a quote or sample for 2-(Difluoromethoxy)phenyl isothiocyanate?
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To request a quote or sample, please contact our sales team via the website or by calling us directly. Our team will be pleased to assist you.
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