SR 142948A
SR 142948A (CAS: 184162-21-8; C39H51N5O6·HCl) is a white to beige powder with a molecular weight of 722.31 g/mol. This compound is a potent neurotensin receptor antagonist. It has been utilised in research to investigate the intricate roles of neurotensin signalling pathways, particularly in relation to intracellular alkanization and the expression of interleukin-8 (IL-8) in human pancreatic cancer cells. Available with an assay of ≥98% (HPLC).
- IUPAC
- 2-[[5-(2,6-dimethoxyphenyl)-1-(4-(N-(3-dimethylaminopropyl)-N-methylcarbamoyl)-2-isopropylphenyl)-1H-pyrazole3-carbonyl]amino] adamantane-2-carboxylic acid hydrochloride,SR 142948 hydrochloride
- Synonyms
- 2-[[5-(2,6-dimethoxyphenyl)-1-(4-(N-(3-dimethylaminopropyl)-N-methylcarbamoyl)-2-isopropylphenyl)-1H-pyrazole3-carbonyl]amino] adamantane-2-carboxylic acid hydrochloride,SR 142948 hydrochloride
Neurotensin Receptor Antagonism Research
SR 142948A functions as a selective antagonist of neurotensin receptors. It is employed in preclinical studies to elucidate the physiological and pathological functions of the neurotensin system.
Cancer Cell Signalling Studies
This compound has been used to examine the involvement of neurotensin signalling in modulating intracellular pH and the expression of IL-8 in human pancreatic cancer cell lines, providing insights into potential therapeutic targets.
GPCR Modulation Research
As a modulator of G-protein coupled receptors (GPCRs), SR 142948A is valuable for researchers studying GPCR function, particularly in the context of neuroscience and cell signalling.
| Molecular weight | 722.31 |
|---|---|
| Empirical formula | C39H51N5O6·HCl |
| Assay | ≥98% (HPLC) |
| Form | powder |
| Colour | white to beige |
| Solubility | H2O: ≥2 mg/mL at warmed to 60 °C |
| Storage temperature | 2-8°C |
| Application | SR 142948A was used to study the role of neurotensin signaling in intracellular alkanization and expression of IL-8 in human pancreatic cancer cells.1 |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is SR 142948A used for?
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SR 142948A is primarily used in scientific research as a neurotensin receptor antagonist to study its role in intracellular alkanization and IL-8 expression in human pancreatic cancer cells. It is also utilized in broader GPCR modulation and cell signalling research.
What is the CAS number and formula for SR 142948A?
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The CAS number for SR 142948A is 184162-21-8 and its empirical formula is C39H51N5O6·HCl.
What grade and purity does Tech Serve Solutions supply for SR 142948A?
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Tech Serve Solutions supplies SR 142948A with an assay of ≥98% by HPLC. We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
What are the safety and handling recommendations for SR 142948A?
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SR 142948A is classified with a WGK Germany of 3, indicating it is hazardous to water. Handle with appropriate personal protective equipment in a well-ventilated area. Refer to the Safety Data Sheet (SDS) for comprehensive handling and disposal information.
How is SR 142948A stored and shipped?
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SR 142948A should be stored at 2-8°C and is typically supplied as a white to beige powder. Tech Serve Solutions ensures compliant packaging and export procedures for this chemical.
How can I request a sample or quote for SR 142948A?
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To request a sample or a quotation for SR 142948A, please use the 'Request a Quote' or 'Sample Request' form on our website or contact our sales department directly.
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