SR 12813

CAS 126411-39-0C24H42O7P2Biochemicals & Reagents

SR 12813 (CAS: 126411-39-0) is a chemical compound with the molecular formula C24H42O7P2 and a molecular weight of 504.53 g/mol. This solid substance is primarily utilised as a control in various biological assays, specifically in the study of the pregnane X receptor (PXR) in liver carcinoma cells and PXR activation in human hepatocytes. It serves as a valuable tool in research settings for understanding cellular responses and metabolic pathways.

IUPAC: Tetraethyl 2-(3,5-di-tert-butyl-4-hydroxyphenyl)ethenyl-1,1-bisphosphonate

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SR 12813 (C24H42O7P2) — chemical structure, CAS 126411-39-0; Life Science, fine chemical supplied by Tech Serve Solutions

Bioactive Small MoleculesBiochemicals and ReagentsCancer MetabolismCancer ResearchCell BiologyD to KEnzyme InhibitorsEnzyme Inhibitors by EnzymeEnzymesInhibitors

01 /Applications

Pregnane X Receptor (PXR) Binding Assays

SR 12813 is employed as a control substance in PXR binding assays conducted within HepG2 liver carcinoma cells. This application aids researchers in validating experimental conditions and interpreting results related to PXR-ligand interactions.

PXR Activation Studies

The compound serves as a control in studies investigating PXR activation mediated by dehydroepiandrosterone in human hepatocytes. This helps in understanding the role of PXR in cellular responses to specific compounds.

Biochemical Research

As a bioactive small molecule, SR 12813 functions as a biochemical reagent for in vitro research. Its specific use in receptor binding and activation assays makes it relevant for cell biology and cancer research.

02 /Properties

Molecular weight	504.53
Empirical formula	C24H42O7P2
Assay	≥98%
Form	solid
Solubility	DMSO: ≥10 mg/mLH2O: insoluble
Application	SR-12813 was used as control in pregnane X receptor (PXR) binding assay performed in HepG2 liver carcinoma cells1 and PXR-activation assay mediated by dehydroepiandrosterone in human hepatocytes.2

03 /Safety & handling

Protective equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Water hazard class (WGK, DE)	3

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

126411-39-0

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is SR 12813 used for?

SR 12813 is primarily used as a control in pregnane X receptor (PXR) binding assays and PXR-activation assays in cell culture models, such as HepG2 liver carcinoma cells and human hepatocytes. It is a tool for biochemical and cell biology research.

What are the CAS number and chemical formula for SR 12813?

The CAS number for SR 12813 is 126411-39-0, and its empirical formula is C24H42O7P2.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies SR 12813 with an assay of ≥98%. We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade.

How should SR 12813 be handled and stored?

When handling SR 12813, ensure the use of appropriate personal protective equipment, including eyeshields, gloves, and a type N95 (US) or type P1 (EN143) respirator filter. The product is classified with a WGK Germany of 3, indicating a hazard to water. Store in a cool, dry place.