SR 57227A
SR 57227A is a chemical compound with the CAS number 77145-61-0 and the empirical formula C10H14ClN3 · HCl. With a molecular weight of 248.15 g/mol, this white solid is primarily utilised in scientific research for studies involving 5-HT<sub>3</sub>-mediated cell signalling. Its specific application involves investigating cellular responses influenced by this particular signalling pathway, contributing to advancements in neuroscience and related fields.
- IUPAC
- 4-amino-1-(6-chloro-2-pyridyl)-piperidine hydrochloride

Neuroscience Research Tool
SR 57227A serves as a valuable tool in neuroscience research, particularly for investigating the intricate mechanisms of neurotransmission. Its ability to interact with specific cellular signalling pathways makes it suitable for studies aimed at understanding brain function and neurological disorders.
Cell Signalling Studies
This compound is employed in cell biology to explore 5-HT<sub>3</sub>-mediated cell signalling pathways. Researchers utilise SR 57227A to probe the functional roles of serotonin receptors and their downstream effects within cellular systems, aiding in the comprehension of complex biological processes.
GPCR Modulation Research
SR 57227A is relevant for research into G protein-coupled receptors (GPCRs), specifically those involved in serotonergic neurotransmission. It can be used to study the modulation of these receptors, contributing to the development of novel therapeutic strategies.
| Molecular weight | 248.15 |
|---|---|
| Empirical formula | C10H14ClN3 · HCl |
| Form | solid |
| Colour | white |
| Solubility | H2O: soluble9 mg/mL |
| Application | SR 57227A may be used in 5-HT3-mediated cell signaling studies. |

Hazard statements
- H301Toxic if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P301IF SWALLOWED
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 2811 6.1 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T |
| Risk statements (R) | 25-36/37/38 |
| Safety statements (S) | 26-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Gene Information | human ... HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242) |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is SR 57227A used for?
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SR 57227A is used in scientific research for studies involving 5-HT<sub>3</sub>-mediated cell signalling, particularly in neuroscience and cell biology research.
What are the CAS number and formula for SR 57227A?
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The CAS number for SR 57227A is 77145-61-0, and its empirical formula is C10H14ClN3 · HCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies SR 57227A as a research-grade chemical. The specific purity and assay are detailed in the product specifications. TSS does not represent this product as USP, BP, EP, or pharmacopoeia grade unless explicitly stated.
How should SR 57227A be handled safely?
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SR 57227A is classified as dangerous. It is toxic if swallowed (H301), causes skin irritation (H315), eye irritation (H319), and may cause respiratory irritation (H335). Appropriate personal protective equipment, including eyeshields, face shields, gloves, and P2 respirator cartridges, must be used. Handle in a well-ventilated area and follow all safety protocols.
Is SR 57227A packed, shipped, or exported by TSS?
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Yes, Tech Serve Solutions specialises in the global supply and export of fine chemicals, including SR 57227A, adhering to all international shipping regulations for hazardous materials.
How can I request a sample or quote for SR 57227A?
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To request a sample or a quote for SR 57227A, please contact our sales department through the website or by direct inquiry, providing your contact details and intended research application.
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