Sodium dichloroacetate
Sodium dichloroacetate (CAS: 2156-56-1), with the linear formula Cl2CHCO2Na and a molecular weight of 150.92 g/mol, is a sodium salt of dichloroacetic acid. It is primarily recognised for its role as an inhibitor of aerobic glycolysis, particularly the Warburg effect, and is utilised in cancer metabolism research. This compound also finds applications in chemical synthesis and general cell biology studies, serving as a valuable reagent in scientific investigations.
- IUPAC
- Dichloroacetic acid sodium salt
- Synonyms
- Dichloroacetic acid sodium salt
Cancer Metabolism Research
Sodium dichloroacetate is widely employed as a research tool to investigate the Warburg effect and other metabolic alterations characteristic of cancer cells. Its ability to inhibit pyruvate dehydrogenase kinase (PDK) makes it instrumental in studying cancer cell energy production.
Inhibitor of Aerobic Glycolysis
This compound serves as a key inhibitor of aerobic glycolysis, a metabolic phenomenon observed in many cancer types. Researchers utilise it to explore therapeutic strategies targeting cancer cell metabolism.
Chemical Synthesis
As a derivative of dichloroacetic acid, sodium dichloroacetate can be used as a reagent or intermediate in various organic synthesis pathways. Its specific chemical properties lend themselves to tailored synthetic applications.
Cell Biology Studies
In cell biology, sodium dichloroacetate is used to probe cellular metabolic processes and responses to mitochondrial inhibition. Its effects on cellular respiration and energy metabolism are subjects of ongoing research.
| Molecular weight | 150.92 |
|---|---|
| Linear formula | Cl2CHCO2Na |
| Assay | 98% |
| Impurities tested | <2% ethyl alcohol |
| Melting point | 198 °C (dec.)(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
- H351Suspected of causing cancer
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P281Use personal protective equipment as required
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 2 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 36/37/38-40 |
| Safety statements (S) | 26-36/37 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Sodium dichloroacetate used for?
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Sodium dichloroacetate is primarily used in research for its role as an inhibitor of aerobic glycolysis (the Warburg effect) and in studies of cancer metabolism, cell biology, and chemical synthesis. It is also known as a Pyruvate Dehydrogenase Kinase (PDK) inhibitor.
What are the CAS number and chemical formula for Sodium dichloroacetate?
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The CAS number for Sodium dichloroacetate is 2156-56-1. Its linear chemical formula is Cl2CHCO2Na.
What grade and purity does Tech Serve Solutions supply for Sodium dichloroacetate?
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Tech Serve Solutions supplies Sodium dichloroacetate with an assay of 98%. This is generally considered a technical or research grade, and TSS does not represent it as USP, BP, or EP grade.
How should Sodium dichloroacetate be handled safely?
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Handling Sodium dichloroacetate requires appropriate personal protective equipment, including a dust mask (type N95 US), eyeshields, and gloves. It is classified with GHS07 and GHS08 symbols, carrying a Warning signal word. Hazards include H315 (causes skin irritation), H319 (causes serious eye irritation), H335 (may cause respiratory irritation), and H351 (suspected of causing cancer).
How is Sodium dichloroacetate packed and exported?
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Tech Serve Solutions ensures that Sodium dichloroacetate is appropriately packed for shipment and export, adhering to all relevant regulations for chemical handling and transportation.
How can I request a sample or quote for Sodium dichloroacetate?
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To request a sample or obtain a quote for Sodium dichloroacetate, please contact our sales team directly through the website or by phone.
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