Sodium cyanoborohydride
Sodium cyanoborohydride (CAS: 25895-60-7; Formula: NaBH3CN; Molar Mass: 62.84) is a selective reducing agent supplied by Tech Serve Solutions. It is primarily utilized in organic synthesis for the reductive amination of aldehydes and ketones, as well as the reductive alkylation of amines. Its ability to selectively reduce imines over carbonyls makes it a valuable reagent in various chemical transformations.
- IUPAC
- Sodium cyanotrihydridoborate
- Synonyms
- Sodium cyanotrihydridoborate
Reductive Amination
Sodium cyanoborohydride is a key reagent for the reductive amination of aldehydes and ketones. It facilitates the formation of amines from carbonyl compounds and ammonia or primary/secondary amines in a single step.
Reductive Alkylation
This compound is effective in the reductive alkylation of amines. It allows for the introduction of alkyl groups onto amine functionalities under mild conditions.
Selective Reduction
Its selective reducing power allows for the reduction of iminium ions formed in situ from carbonyl compounds and amines, while leaving the carbonyl group largely unaffected.
Glycobiology and Proteomics
Sodium cyanoborohydride finds applications in glycobiology and proteomics for glycan labeling and analysis, contributing to the study of post-translational modifications.
| Molecular weight | 62.84 |
|---|---|
| Linear formula | NaBH3CN |
| Assay | 97.5-102.5 wt. % (redox titration) |
| Grade | reagent grade |
| Density | 0.915 g/mL at 25 °C |
| Solubility | H2O: soluble100 mg/mL, clear to faintly turbid, colorless |
| Concentration | 1.0 M in THF |
| Melting point | >242 °C (dec.)(lit.) |
| Impurities tested | ≤720 mg/kg residual solvent (tetrahydrofuran)≤890 mg/kg residual solvent (toluene) |
| Application | Reagent employed in the reductive amination of aldehydes1 and ketones,2 and in the reductive alkylation of amines.3 |
| Suitability | suitable for manufacturing use |
Hazard statements
- H228Flammable solid
- H300Fatal if swallowed
- H314Causes severe skin burns and eye damage
- H410Very toxic to aquatic life with long-lasting effects
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P260Do not breathe dust, fume, gas, mist, vapours or spray
- P264Wash thoroughly after handling
- P273Avoid release to the environment
- P280Wear protective gloves, clothing and eye/face protection
- P284Wear respiratory protection
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 3179 4.1/PG 2 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,T+,N |
| Risk statements (R) | 11-26/27/28-32-34-50/53 |
| Safety statements (S) | 26-28-36/37/39-45-60-61 |
| Supplemental hazards | Contact with acids liberates very toxic gas. |
| Cation traces | Ag: ≤2.5 mg/kgCd: ≤2.5 mg/kgCr: ≤2.5 mg/kgCu: ≤10 mg/kgFe: ≤10 mg/kgMo: ≤2.5 mg/LNi: ≤2.5 mg/kg |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Sodium Cyanoborohydride used for?
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Sodium cyanoborohydride (CAS: 25895-60-7) is a selective reducing agent used in organic synthesis, particularly for the reductive amination of aldehydes and ketones, and the reductive alkylation of amines. It also has applications in glycobiology and proteomics.
What is the CAS number and formula for Sodium Cyanoborohydride?
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The CAS number for Sodium Cyanoborohydride is 25895-60-7, and its linear formula is NaBH3CN.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Sodium Cyanoborohydride as reagent grade with an assay of 97.5-102.5 wt. % (redox titration). TSS does not represent this product as USP, BP, or EP grade.
How should Sodium Cyanoborohydride be handled safely?
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Sodium cyanoborohydride is a dangerous substance. It is flammable and toxic, and contact with acids liberates very toxic gas. Appropriate personal protective equipment, including eyeshields, gloves, and respiratory protection, must be used. Store in a well-ventilated place and keep away from heat and open flames.
Is Sodium Cyanoborohydride a controlled substance?
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The provided data does not indicate that Sodium Cyanoborohydride is a controlled substance.
How is Sodium Cyanoborohydride packed and shipped?
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Sodium cyanoborohydride is typically supplied in appropriate packaging for safe handling and transport. For export, all relevant international regulations for hazardous materials are adhered to.
How can I request a quote or sample for Sodium Cyanoborohydride?
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To request a quote or sample for Sodium Cyanoborohydride, please contact our sales team through the website or by phone.
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