5-Methoxy-3-indoleacetic acid
5-Methoxy-3-indoleacetic acid (CAS: 3471-31-6, C11H11NO3) is a specialised chemical building block with a molecular weight of 205.21 g/mol. It is primarily utilised as a reactant in the synthesis of various complex organic molecules. Its applications span the development of novel therapeutic agents, including inhibitors of nitric oxide production, potential anti-tumour agents, and antagonists for specific cellular receptors, highlighting its importance in medicinal chemistry research and development.
- IUPAC
- 2-(5-Methoxy-3-indolyl)acetic acid
- Synonyms
- 2-(5-Methoxy-3-indolyl)acetic acid
Preparation of NO Production Inhibitors
Serves as a key reactant in the synthesis of aryloxybenzothiazoles, which have demonstrated inhibitory effects on nitric oxide production.
Development of Antitumor Agents
Utilised in the preparation of novel Gli1 transcription inhibitors, showing potential as anti-tumour agents in research settings.
Synthesis of Receptor Antagonists
Employed in the synthesis of indole derivatives that function as NR2B/NMDA receptor antagonists and prostaglandin D2 receptor antagonists.
Creation of COX-2 Inhibitors
Acts as a reactant in creating indolyl esters and amides structurally related to indomethacin, investigated as selective COX-2 inhibitors.
Preparation of P-Selectin Antagonists
Used as a reactant in the synthesis of the quinoline salicylic acid series, which are explored for their P-selectin antagonist properties.
| Molecular weight | 205.21 |
|---|---|
| Empirical formula | C11H11NO3 |
| Assay | 98% |
| Application | • Reactant for preparation of aryloxybenzothiazoles as inhibitors of NO production1• Reactant for preparation of transcription inhibitors of novel Gli1 as antitumor agents• Reactant for preparation of indole derivatives as NR2B/NMDA receptor antagonists2• Reactant for preparation of indolyl esters and amides related to indomethacin as selective COX-2 inhibitors3• Reactant for preparation of quinoline salicylic acid series of P-selectin antagonists4• Reactant for preparation of prostaglandin D2 receptor antagonists5 |
| Melting point | 145-148 °C (dec.)(lit.) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 5-Methoxy-3-indoleacetic acid used for?
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5-Methoxy-3-indoleacetic acid is used as a reactant in the synthesis of various organic compounds, including potential therapeutic agents like nitric oxide production inhibitors, anti-tumour agents, NR2B/NMDA receptor antagonists, COX-2 inhibitors, and P-selectin antagonists.
What are the CAS number and chemical formula for 5-Methoxy-3-indoleacetic acid?
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The CAS number for 5-Methoxy-3-indoleacetic acid is 3471-31-6, and its chemical formula is C11H11NO3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 5-Methoxy-3-indoleacetic acid with an assay of 98%. We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
What are the safety and handling precautions for 5-Methoxy-3-indoleacetic acid?
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Handle with appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is recommended. The substance has a WGK Germany classification of 3, indicating it is hazardous to water.
How is 5-Methoxy-3-indoleacetic acid packed and shipped?
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5-Methoxy-3-indoleacetic acid is carefully packed for safe transit and exported globally by Tech Serve Solutions, adhering to all relevant shipping regulations.
How can I request a sample or quote for 5-Methoxy-3-indoleacetic acid?
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To request a sample or a quotation for 5-Methoxy-3-indoleacetic acid, please contact our sales team through the website or by phone.
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