SL327

CAS 305350-87-2C16H12F3N3SCell Biology

SL327 (CAS: 305350-87-2) is a potent selective MEK inhibitor with the molecular formula C16H12F3N3S and a molecular weight of 335.35 g/mol. This white to off-white solid is primarily used in research to investigate the mitogen-activated protein kinase (MAPK) signaling pathway. Its applications extend to cell biology, cell signaling studies, and neuroscience research, aiding in the understanding of various cellular processes and disease mechanisms.

IUPAC: α-[Amino-(4-aminophenylthio)methylene)-2-(trifluoromethyl)phenylacetonitrile,SL 327,SL-327

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SL327 (C16H12F3N3S) — chemical structure, CAS 305350-87-2; Life Science, fine chemical supplied by Tech Serve Solutions

Bioactive Small MoleculesCell BiologyKinase/Phosphatase Biology

01 /Applications

Investigation of MAPK Signaling in Epilepsy

SL327 has been utilised in studies examining the role of MAPK signaling in the development of interictal spiking and behavioural changes associated with epilepsy in rat models.

Estradiol Effects on ERK Signaling

Researchers have employed SL327 to investigate the impact of estradiol on ERK signaling pathways within the dorsal hippocampus of mice.

Cell Biology and Signaling Research

As a selective MEK inhibitor, SL327 is a valuable tool for researchers studying cell proliferation, differentiation, and survival regulated by the MAPK pathway.

Neuroscience Research

This compound aids in exploring the complex signaling cascades involved in neuronal function and response, contributing to advancements in neuroscience.

02 /Properties

Molecular weight	335.35
Empirical formula	C16H12F3N3S
Assay	≥98% (HPLC)
Form	solid
Colour	white to off-white
Solubility	DMSO: >10 mg/mLH2O: insoluble
Storage temperature	2-8°C
Melting point	127-128.2 °C
Application	SL327 was used to study the role of MAPK signaling in interictal spiking and behavior of epileptic rats.1 It was used to study the effect of estradiol on ERK signaling in mouse dorsal hippocampus.2

03 /Safety & handling

Protective equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Water hazard class (WGK, DE)	3

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

305350-87-2

05 /Additional specifications

Storage Condition	desiccatedprotect from light

06 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

07 /Frequently asked questions

What is SL327 used for?

SL327 is primarily used in research to investigate the mitogen-activated protein kinase (MAPK) signaling pathway, including its role in epilepsy and the effects of estradiol on ERK signaling.

What is the CAS number and molecular formula for SL327?

The CAS number for SL327 is 305350-87-2, and its molecular formula is C16H12F3N3S.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies SL327 with a purity of ≥98% (HPLC). We do not represent this product as USP, BP, or EP grade.

How should SL327 be handled and stored?

Handle SL327 with appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is recommended. Store the compound desiccated, protected from light, at 2-8°C.

Is SL327 a controlled substance?

The provided data does not indicate that SL327 is a controlled substance.

How is SL327 shipped and exported?

Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals. SL327 is shipped and exported adhering to all relevant regulations for chemical transport.