SKI II
SKI II (CAS 312636-16-1), with the empirical formula C15H11ClN2OS and a molecular weight of 302.78 g/mol, is an off-white solid compound. It is recognised for its role as an inhibitor, particularly in studies of sphingolipid metabolism and cell signalling. This chemical serves as a valuable tool in biochemical research, aiding investigations into cellular processes and disease mechanisms, especially within the fields of cell biology and neuroscience.
- IUPAC
- 4-[[4-(4-Chlorophenyl)-2-thiazolyl]amino]phenol
Research in Drug Resistance Mechanisms
Human cisplatin-resistant gastric cancer cell lines have been treated with SKI-II to investigate the mechanisms by which multidrug resistance can be reverted. This application is crucial for understanding and potentially overcoming resistance to cancer therapies.
Investigation of Kinase/Phosphatase Biology
SKI-II is utilized in research focusing on kinase and phosphatase biology. Its inhibitory properties make it a useful compound for studying the roles of these enzymes in various cellular pathways and signalling cascades.
Cellular Metabolism Studies
The compound finds application in exploring metabolic pathways, specifically within sphingolipid metabolism. Researchers use SKI-II to probe the functions and regulation of these pathways at a cellular level.
| Molecular weight | 302.78 |
|---|---|
| Empirical formula | C15H11ClN2OS |
| Assay | ≥98% (HPLC) |
| Form | solid |
| Colour | off-white |
| Solubility | DMSO: ≥20 mg/mL |
| Storage temperature | 2-8°C |
| Application | Human cisplatin-resistant gastric cancer cell line was treated with SKI-II to study the mechanism of reversion of multidrug resistance.1 |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Storage Condition | protect from light |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is SKI II used for?
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SKI II is used in biochemical research, particularly for investigating cellular processes, cell signalling, neuroscience, and sphingolipid metabolism. It has been applied in studies concerning drug resistance mechanisms in cancer cell lines and kinase/phosphatase biology.
What are the CAS number and formula for SKI II?
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The CAS number for SKI II is 312636-16-1, and its empirical formula is C15H11ClN2OS.
What grade and purity does Tech Serve Solutions supply for SKI II?
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Tech Serve Solutions supplies SKI II with an assay of ≥98% (HPLC). This product is intended for research and laboratory use and is not represented as USP, BP, EP, or pharmacopoeia grade.
How should SKI II be handled and stored?
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SKI II is a solid compound that should be stored at 2-8°C, protected from light. When handling, it is advised to use appropriate personal protective equipment, including eyeshields, gloves, and a type N95 (US) or type P1 (EN143) respirator filter. Appropriate handling procedures should be followed as per laboratory safety protocols.
Is SKI II a controlled substance?
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The provided data does not indicate that SKI II is a controlled substance.
How is SKI II typically shipped and exported?
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Tech Serve Solutions, as a global supplier, ships and exports fine chemicals like SKI II following all relevant international regulations for chemical transport and export. Specific shipping details can be provided upon inquiry.
How can I request a quote or sample for SKI II?
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To request a quote or sample for SKI II, please contact our sales team through the website or by phone. Our representatives will be pleased to assist you with your specific requirements.
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