SKF-94836
SKF-94836 (CAS: 115344-47-3), with the molecular formula C14H16N6O and a molecular weight of 284.32, is a white solid compound supplied by Tech Serve Solutions. It functions as a phosphodiesterase inhibitor and is utilised in biochemical research. Specifically, it has been employed to investigate the role of phosphodiesterases in the proliferative responses of human peripheral blood mononuclear cells (PBMCs) to antigens and mitogens. SKF-94836 is soluble in DMSO.
- IUPAC
- N-Cyano-N′-methyl-N″-[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]guanidine,Siguazodan
Research into Phosphodiesterase Function
SKF-94836 is used as a tool compound in research settings to explore the activity and function of phosphodiesterase enzymes. Its inhibitory properties allow for the investigation of cellular signaling pathways regulated by cyclic nucleotides.
Study of Cellular Proliferation
The compound has been utilised to examine the role of phosphodiesterases in antigen and mitogen-induced proliferative responses in human PBMCs. This application helps elucidate mechanisms of immune cell activation and regulation.
Biochemical and Cell Signaling Research
As a bioactive small molecule, SKF-94836 is valuable for studies in cell biology, cell signaling, and neuroscience, particularly concerning cyclic nucleotide metabolism and G protein pathways.
| Molecular weight | 284.32 |
|---|---|
| Empirical formula | C14H16N6O |
| Assay | >99% (HPLC) |
| Form | solid |
| Colour | white |
| Solubility | DMSO: freely soluble >5 mg/mL |
| Storage temperature | 2-8°C |
| Melting point | 268-268.9 °C(lit.) |
| Application | Human PBMCs were treated with SKF-94836 to study the role of phosphodiesterases in antigen and mitogen-induced proliferative responses.1 |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Gene Information | human ... PDE3A(5139), PDE3B(5140) |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is SKF-94836 primarily used for?
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SKF-94836 is primarily used in biochemical research as a phosphodiesterase inhibitor to study cellular proliferation and signaling pathways, particularly involving cyclic nucleotides and PBMCs.
What is the CAS number and molecular formula for SKF-94836?
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The CAS number for SKF-94836 is 115344-47-3, and its molecular formula is C14H16N6O.
What grade and purity does Tech Serve Solutions supply for SKF-94836?
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Tech Serve Solutions supplies SKF-94836 with a purity of >99% (HPLC). This product is intended for research purposes and is not supplied as USP, BP, or EP grade.
How should SKF-94836 be handled safely?
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SKF-94836 is a Warning substance with H315, H319, and H335 hazard statements, indicating it causes skin irritation, serious eye irritation, and may cause respiratory irritation. Handle with appropriate personal protective equipment, including a dust mask (N95 US type), eyeshields, and gloves, in a well-ventilated area. Avoid breathing dust. P261 and P305+P351+P338 precautionary statements apply.
How is SKF-94836 packed and shipped?
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SKF-94836 is typically stored at 2-8°C. It is packed securely for export, adhering to international shipping regulations for chemical substances.
How can I request a quote or sample for SKF-94836?
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To request a quote or sample of SKF-94836, please contact our sales department through the website or via email, providing your contact details and the quantity required.
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