SMI-4a
SMI-4a (CAS: 438190-29-5), a trifluoromethyl-substituted thiazolidinedione derivative with the empirical formula C11H6F3NO2S and a molecular weight of 273.23 g/mol, is a specialised chemical reagent. It is primarily utilised in biochemical research, particularly within cell biology and cell signalling studies. This compound serves as a valuable tool for investigating kinase/phosphatase pathways, including the Pim1 oncogene, offering insights into serine/threonine kinase biology and inhibition mechanisms.
- IUPAC
- (5Z)-5-[[3-(Trifluoromethyl)phenyl]methylene]-2,4-thiazolidinedione,(Z)-5-(3-Trifluoromethylbenzylidene)thiazolidine-2,4-dione
- Synonyms
- (5Z)-5-[[3-(Trifluoromethyl)phenyl]methylene]-2,4-thiazolidinedione(Z)-5-(3-Trifluoromethylbenzylidene)thiazolidine-2,4-dione
Kinase/Phosphatase Pathway Research
SMI-4a is employed as a selective inhibitor in studies of serine/threonine kinases, providing researchers with a tool to investigate signal transduction pathways. Its application is crucial for understanding the role of kinases like Pim1 in cellular processes.
Cellular Signalling Investigations
This compound aids in elucidating complex cell signalling mechanisms, particularly those involving kinase cascades. Researchers use SMI-4a to probe the effects of kinase inhibition on cellular behaviour and function.
Neuroscience Research Tool
Within neuroscience, SMI-4a can be utilised to study the involvement of specific kinase pathways in neuronal function and disorders. Its inhibitory properties offer a means to explore molecular mechanisms in the nervous system.
| Molecular weight | 273.23 |
|---|---|
| Empirical formula | C11H6F3NO2S |
| Assay | ≥98% (HPLC) |
| Form | powder |
| Colour | white to beige |
| Solubility | DMSO: >10 mg/mL |
| Storage temperature | 2-8°C |
Hazard statements
- H317May cause an allergic skin reaction
- H319Causes serious eye irritation
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Water hazard class (WGK, DE) | 3 |
|---|---|
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36-43 |
| Safety statements (S) | 26-36/37 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is SMI-4a used for?
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SMI-4a is used in biochemical research, particularly in cell biology, cell signalling, and neuroscience. It serves as an inhibitor for studying kinase/phosphatase pathways, including the Pim1 oncogene and serine/threonine kinases.
What is the CAS number and empirical formula for SMI-4a?
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The CAS number for SMI-4a is 438190-29-5, and its empirical formula is C11H6F3NO2S.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies SMI-4a with a purity of ≥98% (HPLC). TSS does not represent this product as USP, BP, or EP grade.
What are the safety and handling recommendations for SMI-4a?
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SMI-4a is classified with a GHS07 symbol and a Warning signal word. It carries hazard statements H317 (May cause an allergic skin reaction) and H319 (Causes serious eye irritation). Users should wear protective gloves and eye protection (P280, P305 + P351 + P338).
How is SMI-4a shipped and exported?
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SMI-4a is typically stored at 2-8°C. Tech Serve Solutions, a global supplier and exporter, can provide details on shipping and export procedures upon request.
How can I request a sample or quote for SMI-4a?
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To request a sample or a quote for SMI-4a, please contact Tech Serve Solutions directly through our website or sales department.
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