SB 203580
SB 203580 (CAS 152121-47-6), with the empirical formula C21H16FN3OS and a molecular weight of 377.43 g/mol, is a potent inhibitor primarily targeting p38 MAP kinase. This compound is supplied as a white to off-white solid. It finds application in cell biology research, particularly in studying cellular signaling pathways, kinase inhibition, and gene expression related to inflammatory responses and stress.
- IUPAC
- 4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazole
MAPK Signaling Pathway Research
SB 203580 is utilised to investigate the role of MAPK signaling in cellular processes, such as inducing hypertonicity of cell membranes and potassium depletion, as observed in MDCK cells.
Neuroscience Studies
This inhibitor has been employed to modulate MAPK signaling in experimental models, including mouse cortical neurons, to understand its impact on neuronal function and response.
Cancer Cell Line Investigations
Research involving human hepatocellular carcinoma cell lines has utilised SB 203580 to probe the involvement of MAPK pathways in the development and progression of these cancers.
| Molecular weight | 377.43 |
|---|---|
| Empirical formula | C21H16FN3OS |
| Assay | ≥98% (HPLC) |
| Form | solid |
| Colour | white to off-white |
| Solubility | DMSO: ≥20 mg/mL |
| Storage temperature | −20°C |
| Application | MDCK cells were treated with SB 203580 to study the role of MAPK signaling in inducing hypertonicity of cell membrane and potassium depletion.16 It was used to inhibit MAPK signaling in mouse cortical neurons17 and human hepatocellular carcinoma cell lines.18 |
Hazard statements
- H302Harmful if swallowed
- H318Causes serious eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22-41 |
| Safety statements (S) | 26-39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is SB 203580 used for?
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SB 203580 is primarily used in research to inhibit p38 MAP kinase and study its role in cellular signaling pathways, gene expression, and various cellular responses in models including cell lines and neurons.
What are the CAS number and chemical formula for SB 203580?
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The CAS number for SB 203580 is 152121-47-6, and its empirical formula is C21H16FN3OS.
What grade and purity does Tech Serve Solutions supply for SB 203580?
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Tech Serve Solutions supplies SB 203580 with an assay of ≥98% (HPLC). We do not represent this product as USP, BP, or EP grade; it is intended for research and laboratory use.
How should SB 203580 be handled safely?
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SB 203580 is classified as harmful if swallowed and causes serious eye damage (H302, H318). When handling, it is essential to wear appropriate personal protective equipment, including eyeshields, gloves, and a dust mask (type N95 US), and to avoid contact with eyes and skin. Ensure adequate ventilation.
How is SB 203580 packaged and shipped?
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SB 203580 is typically supplied as a solid and stored at -20°C. TSS is a global supplier and exporter of fine chemicals, adhering to international shipping regulations.
How can I request a sample or quote for SB 203580?
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To request a sample or a quote for SB 203580, please contact our sales team through the TSS website or by calling our dedicated order line.
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