SB 242084 dihydrochloride hydrate
SB 242084 dihydrochloride hydrate (CAS: 181632-25-7 free base) is a chemical compound with the formula C21H19ClN4O2 · 2HCl · xH2O and a molecular weight of 467.78 (anhydrous basis). This white to beige powder is primarily utilised in scientific research for its role as a selective 5-HT2C receptor antagonist. It has been instrumental in investigating the modulation of food intake behaviours, particularly in preclinical rodent models.
- IUPAC
- 6-Chloro-2,3-dihydro-5-methyl-N-[6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinyl]-1H-indole-1-carboxyamide dihydrochloride hydrate,6-Chloro-5-methyl-1-[[2-(2-methylpyrid-3-yloxy)pyrid-5-yl]carbamoyl]indoline dihydrochloride hydrate
- Synonyms
- 6-Chloro-2,3-dihydro-5-methyl-N-[6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinyl]-1H-indole-1-carboxamide dihydrochloride hydrate6-Chloro-5-methyl-1-[[2-(2-methylpyrid-3-yloxy)pyrid-5-yl]carbamoyl]indoline dihydrochloride hydrate
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Neuroscience Research
SB 242084 dihydrochloride hydrate serves as a valuable tool in neuroscience research, specifically for studying the serotonergic system. Its ability to antagonise 5-HT2C receptors allows researchers to investigate the role of these receptors in various neurological functions and behaviours.
Investigating Food Intake
This compound has been employed in studies examining the regulation of appetite and food intake. By blocking 5-HT2C receptors, researchers can explore their contribution to satiety and energy balance, as demonstrated in rodent models.
GPCR Modulator Studies
As a modulator of G protein-coupled receptors (GPCRs), SB 242084 dihydrochloride hydrate is used to explore the complex signalling pathways involved in cellular responses. It is particularly relevant for research focused on GPCRs in the central nervous system.
| Molecular weight | 467.78 (anhydrous basis) |
|---|---|
| Empirical formula | C21H19ClN4O2 · 2HCl · xH2O |
| Assay | ≥98% (HPLC) |
| Form | powder |
| Colour | white to beige |
| Solubility | DMSO: soluble15 mg/mL, clearH2O: soluble5 mg/mL, clear |
| Storage temperature | 2-8°C |
| Application | SB 242084 dihydrochloride hydrate was used to study the role of 5-HT2C on food intake behavior of rats.4,5 |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Storage Condition | desiccated |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is SB 242084 dihydrochloride hydrate used for?
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SB 242084 dihydrochloride hydrate is primarily used in scientific research as a selective 5-HT2C receptor antagonist to study its role in food intake behaviour and other neurological functions.
What is the CAS number and chemical formula?
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The CAS number for the free base is 181632-25-7. The empirical formula is C21H19ClN4O2 · 2HCl · xH2O.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies SB 242084 dihydrochloride hydrate with an assay of ≥98% (HPLC). This product is not classified as USP, BP, or EP grade.
How should SB 242084 dihydrochloride hydrate be handled and stored?
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Handle with appropriate personal protective equipment, including a dust mask (N95), eyeshields, and gloves, due to potential irritation to the skin, eyes, and respiratory tract (H315, H319, H335). Store desiccated at 2-8°C.
Is this product shipped or exported internationally?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals and reagents, including SB 242084 dihydrochloride hydrate.
How can I request a quote or sample?
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Please contact our sales team directly through our website or by phone to request a quote or a sample of SB 242084 dihydrochloride hydrate.
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