SB 202190
SB 202190 (CAS: 152121-30-7, C20H14FN3O) is a research chemical with a molecular weight of 331.34 g/mol. It is an established inhibitor of p38 activation, with applications in cellular studies. Supplied by TSS as a pale yellow solid, it is suitable for various biochemical and cell biology research applications, aiding in the investigation of cellular signalling pathways. Its specific inhibitory action makes it a valuable tool in neuroscience and kinase/phosphatase research.
- IUPAC
- 4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole
p38 MAPK Inhibition Studies
SB 202190 is utilised to inhibit p38 activation in cellular models, including MCF7 cells, mouse macrophages, and HepG2 cells. This application supports research into inflammatory responses and cellular signalling pathways regulated by p38.
Cellular Signalling Research
As a bioactive small molecule, SB 202190 serves as a tool in cell biology and cell signalling research. Its specific inhibitory properties aid in elucidating the roles of p38 MAPK in various cellular processes.
Drug Candidate Research
Classified under Approved Therapeutics/Drug Candidates, SB 202190 is relevant for early-stage drug discovery and development, particularly in areas involving kinase inhibition and inflammatory diseases.
| Molecular weight | 331.34 |
|---|---|
| Empirical formula | C20H14FN3O |
| Assay | ≥98% (HPLC) |
| Colour | pale yellow |
| Solubility | DMSO: soluble30 mg/mL |
| Storage temperature | 2-8°C |
| Application | SB 202190 was used to inhibit p38 activation in MCF7 cells5, mouse macrophages6 and HepG2 cells.7 |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36/37 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Gene Information | human ... MAPK14(1432) |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is SB 202190 used for?
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SB 202190 is used as an inhibitor of p38 activation in various cell types, including MCF7, mouse macrophages, and HepG2 cells, making it valuable for cell biology, cell signalling, and kinase inhibition research.
What is the CAS number and molecular formula for SB 202190?
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The CAS number for SB 202190 is 152121-30-7, and its molecular formula is C20H14FN3O.
What grade and purity does Tech Serve Solutions supply for SB 202190?
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Tech Serve Solutions supplies SB 202190 with a purity of ≥98% (HPLC). This product is intended for research purposes and is not represented as USP, BP, or EP grade.
What are the safety and handling recommendations for SB 202190?
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SB 202190 is classified with a GHS07 symbol and 'Warning' signal word, carrying hazard statements H315, H319, and H335 (causes skin irritation, serious eye irritation, and may cause respiratory irritation). It requires the use of a dust mask type N95 (US), eyeshields, and gloves. Store at 2-8°C. For detailed safety information, consult the product's Safety Data Sheet.
How is SB 202190 packed and exported by TSS?
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SB 202190 is available from Tech Serve Solutions and is packed and exported according to industry standards for chemical reagents, ensuring safe transit for global customers.
How can I request a quote or sample for SB 202190?
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To request a quote or a sample of SB 202190, please contact the TSS sales team via our website or direct email, providing your specific requirements.
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