SB 202190 monohydrochloride hydrate
SB 202190 monohydrochloride hydrate (CAS 350228-36-3) is a chemical compound with the formula C20H14FN3O · HCl · xH2O and a molecular weight of 367.80 (anhydrous basis). This solid substance, with an assay of ≥98% by HPLC, is primarily utilised as a p38 mitogen-activated protein kinase (p38MAPK) inhibitor. It plays a role in research settings for investigating cell signaling pathways, particularly in areas related to inflammation and stress responses.
- IUPAC
- 4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole monohydrochloride hydrate,4-[4-(4-Fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]phenol monohydrochloride hydrate
- Synonyms
- 4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole monohydrochloride hydrate,4-[4-(4-Fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]phenol monohydrochloride hydrate
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p38 MAPK Inhibition
SB 202190 is employed to selectively inhibit the activity of p38 mitogen-activated protein kinase (p38MAPK). This kinase plays a crucial role in cellular responses to stress and inflammation.
Cell Signaling Research
As a tool compound, it aids in dissecting signalling cascades involving p38MAPK. Its application helps researchers understand the downstream effects of p38 pathway activation in various cellular contexts.
Approved Therapeutics Research
Classified under approved therapeutics/drug candidates, SB 202190 is of interest in preclinical research for potential therapeutic strategies targeting pathways regulated by p38MAPK.
| Molecular weight | 367.80 (anhydrous basis) |
|---|---|
| Empirical formula | C20H14FN3O · HCl · xH2O |
| Assay | ≥98% (HPLC) |
| Form | solid |
| Solubility | DMSO: ≥12 mg/mL |
| Storage temperature | 2-8°C |
| Application | SB 202190 may be used to inhibit p38-mediated cell signaling. |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Water hazard class (WGK, DE) | 3 |
|---|---|
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36/37 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is SB 202190 monohydrochloride hydrate used for?
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SB 202190 monohydrochloride hydrate is used as a p38 mitogen-activated protein kinase (p38MAPK) inhibitor in research settings to study cell signaling pathways, particularly those involved in stress and inflammation responses.
What is the CAS number and formula for SB 202190 monohydrochloride hydrate?
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The CAS number for the anhydrous form is 350228-36-3. The empirical formula is C20H14FN3O · HCl · xH2O.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies SB 202190 monohydrochloride hydrate with an assay of ≥98% by HPLC. This is a research-grade chemical and is not represented as USP, BP, or EP grade.
How should SB 202190 monohydrochloride hydrate be handled?
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SB 202190 monohydrochloride hydrate is classified as a Warning substance (GHS07) and may cause skin irritation (H315), eye irritation (H319), and respiratory irritation (H335). Handle with appropriate personal protective equipment, avoid breathing dust, and ensure good ventilation.
How is SB 202190 monohydrochloride hydrate shipped?
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This product is typically stored at 2-8°C and is carefully packaged and exported by Tech Serve Solutions to maintain its integrity during transit.
How can I request a quote or sample?
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Please contact Tech Serve Solutions directly through our website or by phone to request a quotation or a sample of SB 202190 monohydrochloride hydrate.
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