SB 216763
SB 216763 (CAS 280744-09-4) is a chemical compound with the formula C19H12N2O2Cl2 and a molecular weight of 371.22 g/mol. It functions as a selective inhibitor of Glycogen Synthase Kinase 3 (GSK-3). This compound is primarily utilised in research settings for investigating cellular signalling pathways, particularly within neuroscience and cell biology, due to its role in modulating GSK-3β activity.
- IUPAC
- 3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
- Synonyms
- 3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
GSK-3β Inhibition in Cellular Studies
SB 216763 is employed to selectively inhibit GSK-3β activity in various cell types, including human brain microvascular endothelial cells and colorectal cancer cells, facilitating research into cellular signalling pathways.
Neuroscience Research Tool
As a potent inhibitor of GSK-3, SB 216763 is valuable in neuroscience research for exploring the role of GSK-3 in neuronal function and disease.
Cancer Biology Investigations
The compound has been used in studies investigating the role of GSK-3 in the proliferation and signalling of cancer cells, such as colorectal cancer.
| Molecular weight | 371.22 |
|---|---|
| Empirical formula | C19H12N2O2Cl2 |
| Assay | >98% (HPLC) |
| Colour | orange |
| Solubility | DMSO: soluble20 mg/mLH2O: insoluble |
| Storage temperature | −20°C |
| Application | SB-216763 was used to inhibit GSK-3β in human brain microvascular endothelial cell line1 and colorectal cancer cells.2 |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Gene Information | human ... GSK3A(2931), GSK3B(2932) |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is SB 216763 used for?
+
SB 216763 is primarily used as a selective inhibitor of Glycogen Synthase Kinase 3 (GSK-3) in cellular and molecular biology research, particularly in neuroscience and cancer studies.
What are the CAS number and formula for SB 216763?
+
The CAS number for SB 216763 is 280744-09-4, and its empirical formula is C19H12N2O2Cl2.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies SB 216763 with a purity of >98% (HPLC). We do not represent this product as USP, BP, EP, or any other pharmacopoeial grade.
What are the safety considerations for SB 216763?
+
SB 216763 is classified as a GHS07 substance, presenting a Warning signal word. It is associated with hazard statements H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation). Appropriate personal protective equipment, including a dust mask (type N95), eyeshields, and gloves, should be used during handling. Ensure good ventilation.
How is SB 216763 packed and shipped?
+
SB 216763 is typically stored at -20°C. For export and global supply, it is carefully packaged to maintain integrity and comply with international shipping regulations for research chemicals.
How can I request a sample or quote for SB 216763?
+
To request a sample or obtain a quote for SB 216763, please contact our sales team through the website or via email, providing your specific requirements.
▶ Related products
(−)-Curcumol
C15H24O2
Cell Biology
(±) Clopidogrel hydrogensulfate
Cell Biology
(±)-L-Alliin
C6H11NO3S
Cell Biology
(±)-2-Amino-4-phosphonobutyric acid
C4H10NO5P
Cell Biology
(±)-2-Methylarachidonoyl-2′-fluoroethylamide
C23H38NOF
Cell Biology
(±)-3,4-Methylenedioxy-N-ethylamphetamine hydrochloride
Cell Biology
(±)-3,4-Methylenedioxyamphetamine hydrochloride
Cell Biology
(±)-3,4-Methylenedioxymethamphetamine hydrochloride
Cell Biology
▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis