(S)-α,α-Bis[3,5-bis(trifluoromethyl)phenyl]-2-pyrrolidinemethanol trimethylsilyl ether
(S)-α,α-Bis[3,5-bis(trifluoromethyl)phenyl]-2-pyrrolidinemethanol trimethylsilyl ether (CAS 848821-61-4) is a complex organosilicon compound with the molecular formula C24H23F12NOSi and a molecular weight of 597.51 g/mol. It serves as a valuable chiral auxiliary and ligand in asymmetric synthesis. This proline-derived organocatalyst is crucial for researchers involved in stereoselective chemical transformations, contributing to the development of enantiomerically pure compounds.
- IUPAC
- (S)-α,α-[3,5-Bis(trifluoromethyl)phenyl]prolinol trimethylsilyl ether,(S)-2-[(Bis(3,5-bis(trifluoromethyl)phenyl)trimethylsilanyloxy)methyl]pyrrolidine,(S)-2-[(Bis(3,5-bis(trifluoromethyl)phenyl)trimethylsilyloxy)methyl]pyrrolidine
- Synonyms
- 848821-61-4(S)-α,α-[3,5-Bis(trifluoromethyl)phenyl]prolinol trimethylsilyl ether(S)-2-[(Bis(3,5-bis(trifluoromethyl)phenyl)trimethylsilyloxy)methyl]pyrrolidine(S)-2-[(Bis(3,5-bis(trifluoromethyl)phenyl)trimethylsilanyloxy)methyl]pyrrolidine
![(S)-α,α-Bis[3,5-bis(trifluoromethyl)phenyl]-2-pyrrolidinemethanol trimethylsilyl ether (C24H23F12NOSi) — chemical structure, CAS 848821-61-4; Chemistry, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F848821-61-4.png&w=3840&q=75)
Chiral Ligand in Asymmetric Catalysis
This compound functions as a chiral ligand in metal-catalyzed asymmetric reactions. Its specific structure allows for the induction of enantioselectivity, facilitating the synthesis of chiral molecules with high optical purity. It is particularly useful in transformations requiring precise stereochemical control.
Organocatalysis
As a proline-based organocatalyst, it can promote a variety of asymmetric transformations without the need for metal catalysts. This organocatalyst is employed in reactions such as Diels-Alder cycloadditions, Michael additions, and aldol reactions, offering a metal-free route to enantiomerically enriched products.
Chiral Auxiliary
It can be utilised as a chiral auxiliary, temporarily incorporated into a molecule to direct stereoselective reactions. After the desired transformation, the auxiliary can be cleaved, leaving behind an enantiomerically enriched product and potentially recovering the auxiliary.
| Molecular weight | 597.51 |
|---|---|
| Empirical formula | C24H23F12NOSi |
| Assay | 97% |
| Melting point | 48-56 °C |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Flash point | >110 °C / >230 °F |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36/37 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (S)-α,α-Bis[3,5-bis(trifluoromethyl)phenyl]-2-pyrrolidinemethanol trimethylsilyl ether used for?
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This compound is primarily used as a chiral ligand or organocatalyst in asymmetric synthesis, facilitating stereoselective chemical transformations to produce enantiomerically pure compounds.
What is the CAS number and formula for this chemical?
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The CAS number is 848821-61-4, and its empirical formula is C24H23F12NOSi.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this product at an assay of 97%. It is supplied as a research or technical grade chemical and is not represented as USP, BP, or EP grade.
How should this chemical be handled safely?
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This compound is classified as a Warning, with hazards including skin irritation (H315), eye irritation (H319), and respiratory irritation (H335). Handle with appropriate personal protective equipment, including a dust mask (N95), eyeshields, and gloves. Ensure adequate ventilation and avoid breathing dust.
How is this product packed and shipped?
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This chemical is carefully packed to ensure safe transport and is exported globally by Tech Serve Solutions. Specific packaging details are available upon request.
How can I request a sample or quote?
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To request a sample or a quotation for (S)-α,α-Bis[3,5-bis(trifluoromethyl)phenyl]-2-pyrrolidinemethanol trimethylsilyl ether, please contact our sales team through the website or by phone.
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