(S)-α,α-Bis(3,5-dimethylphenyl)-2-pyrrolidinemethanol
(S)-α,α-Bis(3,5-dimethylphenyl)-2-pyrrolidinemethanol (CAS: 131180-63-7), with the molecular formula C21H27NO and a molecular weight of 309.45 g/mol, is a valuable chiral auxiliary and ligand. It is primarily employed in asymmetric synthesis and chemical catalysis. This proline-based organocatalyst facilitates stereoselective transformations, enabling the synthesis of enantiomerically enriched compounds crucial for pharmaceutical and fine chemical industries.
- IUPAC
- (S)-(−)-2-[Bis(3,5-dimethylphenyl)hydroxymethyl]pyrrolidine
- Synonyms
- 131180-63-7(S)-(−)-2-[Bis(3,5-dimethylphenyl)hydroxymethyl]pyrrolidineC21H27NO
Asymmetric Synthesis
Serves as a chiral auxiliary or catalyst in enantioselective reactions, promoting the formation of specific stereoisomers. It is vital for producing chiral building blocks for complex molecules.
Chiral Ligand in Catalysis
Functions as a ligand in transition metal catalysis, influencing the stereochemical outcome of reactions such as asymmetric hydrogenation or alkylation.
Organocatalysis
As a proline-based organocatalyst, it can mediate various organic transformations without the need for metal catalysts, offering a greener synthetic approach.
Chemical Synthesis Reagent
A key reagent in sophisticated multi-step syntheses within academic research and industrial process development, particularly where chirality control is essential.
| Molecular weight | 309.45 |
|---|---|
| Empirical formula | C21H27NO |
| Assay | ≥99% (HPLC) |
| Optical purity | enantiomeric ratio: 97.5% (HPLC) |
| Storage temperature | 2-8°C |
| Melting point | 98-101 °C |
Hazard statements
- H302Harmful if swallowed
- H400Very toxic to aquatic life
Precautionary statements
- P273Avoid release to the environment
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Transport (UN / ADR) | UN 2811 6.1 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn,N |
| Risk statements (R) | 22-50/53 |
| Safety statements (S) | 60-61 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (S)-α,α-Bis(3,5-dimethylphenyl)-2-pyrrolidinemethanol used for?
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This compound is primarily used in asymmetric synthesis and chemical catalysis as a chiral auxiliary, ligand, or organocatalyst to facilitate stereoselective transformations.
What is the CAS number and formula for this chemical?
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The CAS number is 131180-63-7 and the empirical formula (Hill notation) is C21H27NO.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this chemical with an assay of ≥99% (HPLC) and an optical purity (enantiomeric ratio) of 97.5% (HPLC). This product is not represented as USP, BP, EP, or other pharmacopoeia grades.
How should (S)-α,α-Bis(3,5-dimethylphenyl)-2-pyrrolidinemethanol be handled?
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Handle with appropriate personal protective equipment, including a dust mask (type N95 US recommended), eyeshields, and gloves. Avoid release to the environment as it is harmful to aquatic life with long-lasting effects (H400).
How is this chemical packed and exported?
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This chemical is shipped and exported in compliance with regulations, indicated by UN 2811 (6.1 / PGIII). Storage at 2-8°C is recommended.
How can I request a sample or quote?
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To request a sample or quote, please use the 'Contact Us' form or call our sales department, specifying the product name and CAS number (131180-63-7).
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