(S)-α,α-Bis[3,5-bis(trifluoromethyl)phenyl]-2-pyrrolidinemethanol
(S)-α,α-Bis[3,5-bis(trifluoromethyl)phenyl]-2-pyrrolidinemethanol (CAS: 848821-76-1) is a chiral organocatalyst with the molecular formula C21H15F12NO and a molecular weight of 525.33 g/mol. This compound is extensively employed in asymmetric synthesis, leveraging its specific stereochemistry to induce chirality in various chemical transformations. It serves as a valuable reagent in the development of enantiomerically pure compounds for pharmaceutical and fine chemical applications.
- IUPAC
- (S)-2-{Bis[3,5-bis(trifluoromethyl)phenyl]hydroxymethyl}pyrrolidine
- Synonyms
- 848821-76-1, C21H15F12NO, (S)-2-{Bis[3,5-bis(trifluoromethyl)phenyl]hydroxymethyl}pyrrolidine
![(S)-α,α-Bis[3,5-bis(trifluoromethyl)phenyl]-2-pyrrolidinemethanol (C21H15F12NO) — chemical structure, CAS 848821-76-1; Chemistry, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F848821-76-1.png&w=3840&q=75)
Chiral Catalyst in Asymmetric Synthesis
This compound acts as a highly effective chiral catalyst, facilitating enantioselective reactions. Its unique structure enables the synthesis of specific enantiomers with high optical purity, crucial for pharmaceuticals and advanced materials.
Organocatalysis Reagent
As a proline-based organocatalyst, it participates in various catalytic cycles without the need for metal catalysts. This makes it an attractive option for greener chemical synthesis and where metal contamination is a concern.
Ligand in Catalytic Systems
The molecule can function as a chiral ligand in metal-catalyzed reactions, influencing the stereochemical outcome of the transformation and enhancing selectivity.
| Molecular weight | 525.33 |
|---|---|
| Empirical formula | C21H15F12NO |
| Assay | ≥99.0% (HPLC)≥99.0% |
| Optical purity | ee: ≥99.0% (HPLC) |
| Storage temperature | 2-8°C |
| Melting point | 113-117 °C |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (S)-α,α-Bis[3,5-bis(trifluoromethyl)phenyl]-2-pyrrolidinemethanol used for?
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(S)-α,α-Bis[3,5-bis(trifluoromethyl)phenyl]-2-pyrrolidinemethanol is primarily used as a chiral catalyst and organocatalyst in asymmetric synthesis, enabling the production of enantiomerically pure compounds.
What is the CAS number and formula for this compound?
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The CAS number is 848821-76-1, and the empirical formula (Hill notation) is C21H15F12NO.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this compound with an assay of ≥99.0% (HPLC) and optical purity (ee) of ≥99.0% (HPLC). We do not represent this product as USP, BP, EP, or pharmacopoeia grade.
How should (S)-α,α-Bis[3,5-bis(trifluoromethyl)phenyl]-2-pyrrolidinemethanol be handled?
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Handling requires appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is recommended. Due to its classification (WGK Germany: 3), careful handling to avoid dust generation and contact is advised.
How is this chemical packed, shipped, and exported?
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This chemical is typically stored at 2-8°C. Tech Serve Solutions is a global supplier and exporter, adhering to all necessary regulations for safe and compliant international shipment.
How can I request a sample or quote?
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To request a sample or a quote, please contact our sales department through the website or by calling our customer service line.
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