(S)-4-Fluoro-α-methylbenzylamine
(S)-4-Fluoro-α-methylbenzylamine (CAS: 66399-30-2), a chiral amine with the molecular formula C8H10FN and a molecular weight of 139.17 g/mol, serves as a valuable building block in organic synthesis. It is particularly useful in asymmetric synthesis and the creation of complex organic molecules. Its specific stereochemistry makes it an important intermediate in the pharmaceutical and fine chemical industries for the development of enantiomerically pure compounds.
- IUPAC
- (S)-1-(4-Fluorophenyl)ethylamine

Chiral Building Block in Asymmetric Synthesis
This enantiomerically pure amine is a key intermediate for introducing chirality into target molecules. It is widely used in the synthesis of pharmaceuticals and agrochemicals where specific stereoisomers are crucial for biological activity.
Pharmaceutical Intermediate
The compound is employed in the multi-step synthesis of active pharmaceutical ingredients (APIs). Its fluorinated phenyl group and chiral amine functionality allow for the construction of complex drug candidates.
Organic Synthesis Reagent
Utilised in various organic transformations, this amine can participate in reactions such as amidation, alkylation, and the formation of Schiff bases. Its use contributes to the development of novel organic compounds for research purposes.
| Molecular weight | 139.17 |
|---|---|
| Empirical formula | C8H10FN |
| Assay | ≥98.5% (GC)99% |
| Optical purity | enantiomeric excess: ≥98.5% |



Hazard statements
- H302Harmful if swallowed
- H314Causes severe skin burns and eye damage
- H411Toxic to aquatic life with long-lasting effects
Precautionary statements
- P273Avoid release to the environment
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Transport (UN / ADR) | UN 2735PSN1 8 / PGII |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C,N |
| Risk statements (R) | 22-34-51/53 |
| Safety statements (S) | 26-36/37/39-45-61 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (S)-4-Fluoro-α-methylbenzylamine used for?
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(S)-4-Fluoro-α-methylbenzylamine is primarily used as a chiral building block in asymmetric synthesis and as an intermediate in the pharmaceutical and fine chemical industries for creating enantiomerically pure compounds.
What are the CAS number and molecular formula of (S)-4-Fluoro-α-methylbenzylamine?
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The CAS number for (S)-4-Fluoro-α-methylbenzylamine is 66399-30-2, and its molecular formula is C8H10FN.
What grade and purity does Tech Serve Solutions supply for (S)-4-Fluoro-α-methylbenzylamine?
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Tech Serve Solutions supplies (S)-4-Fluoro-α-methylbenzylamine with an assay of ≥98.5% (GC) and an enantiomeric excess of ≥98.5%. TSS does not represent this product as USP, BP, or EP grade.
How should (S)-4-Fluoro-α-methylbenzylamine be handled safely?
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This compound is classified as Dangerous. It causes severe skin burns and eye damage (H314), is harmful if swallowed (H302), and is toxic to aquatic life with long-lasting effects (H411). Appropriate personal protective equipment, including gloves, eye protection, and protective clothing, must be worn. Handle in a well-ventilated area or fume hood.
Is (S)-4-Fluoro-α-methylbenzylamine shipped internationally?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including (S)-4-Fluoro-α-methylbenzylamine, and can facilitate international shipments.
How can I request a sample or quote for (S)-4-Fluoro-α-methylbenzylamine?
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To request a sample or a quote for (S)-4-Fluoro-α-methylbenzylamine, please contact the Tech Serve Solutions sales team through the website or by phone, providing your specific requirements.
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