(S)-(−)-2-Methyl-2-propanesulfinamide
(S)-(−)-2-Methyl-2-propanesulfinamide (CAS 343338-28-3) is a chiral auxiliary chemical with the molecular formula (CH3)3CS(O)NH2. This sulfur-based compound is primarily utilized in asymmetric synthesis. It can be readily converted into P,N-sulfinyl imine ligands, which are key intermediates in the iridium-catalyzed asymmetric hydrogenation of olefins, enabling the stereoselective synthesis of valuable chiral compounds.
Chiral Auxiliary in Asymmetric Synthesis
(S)-(−)-2-Methyl-2-propanesulfinamide serves as a crucial chiral auxiliary. It is readily condensed with aldehydes and ketones to form P,N-sulfinyl imine ligands. These ligands are instrumental in asymmetric hydrogenation reactions, facilitating the production of enantiomerically enriched products.
Precursor for Chiral Ligands
This sulfinamide is a valuable precursor for synthesizing specialized chiral ligands, particularly P,N-sulfinyl imines. These ligands are employed in transition metal catalysis, such as iridium-catalyzed asymmetric hydrogenation, to control stereochemistry in chemical transformations.
Intermediate in Organic Synthesis
Its structure and reactivity make it a useful intermediate in complex organic synthesis pathways. The compound enables the introduction of chirality and specific functional groups, contributing to the efficient construction of intricate molecular architectures.
| Molecular weight | 121.20 |
|---|---|
| Linear formula | (CH3)3CS(O)NH2 |
| Assay | 97% |
| Optical activity | [α]20/D −4.5°, c = 1 in chloroform |
| Storage temperature | 2-8°C |
| Application | Can be readily transformed into P,N-sulfinyl imine ligands through condensation with aldehydes and ketones, which can undergo iridium-catalyzed asymmetric hydrogenation of olefins.1 |
| Melting point | 97-101 °C(lit.) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (S)-(−)-2-Methyl-2-propanesulfinamide used for?
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(S)-(−)-2-Methyl-2-propanesulfinamide is used as a chiral auxiliary in asymmetric synthesis, particularly for the preparation of P,N-sulfinyl imine ligands for asymmetric hydrogenation of olefins.
What is the CAS number and formula for (S)-(−)-2-Methyl-2-propanesulfinamide?
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The CAS number is 343338-28-3, and its linear formula is (CH3)3CS(O)NH2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies (S)-(−)-2-Methyl-2-propanesulfinamide with an assay of 97%. This product is intended for laboratory and research use. Tech Serve Solutions does not represent this product as USP, EP, BP, or other pharmacopoeial grades.
How should (S)-(−)-2-Methyl-2-propanesulfinamide be handled and stored?
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Handle with appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is recommended. Store at 2-8°C to maintain stability.
Is (S)-(−)-2-Methyl-2-propanesulfinamide a controlled substance?
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The provided data does not indicate that (S)-(−)-2-Methyl-2-propanesulfinamide is a controlled substance.
How is this chemical packed, shipped, and exported?
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Tech Serve Solutions specialises in the global supply and export of fine chemicals. Specific packaging, shipping, and export details for (S)-(−)-2-Methyl-2-propanesulfinamide are available upon request, adhering to international regulations.
How can I request a quote or sample?
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To request a quote or a sample of (S)-(−)-2-Methyl-2-propanesulfinamide, please contact our sales team through the website or by phone. Our experts will assist you promptly.
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