(S)-(−)-2-Hydroxy-4-(2-methoxyphenyl)-5,5-dimethyl-1,3,2-dioxaphosphorinane 2-oxide
(S)-(−)-2-Hydroxy-4-(2-methoxyphenyl)-5,5-dimethyl-1,3,2-dioxaphosphorinane 2-oxide (CAS 98674-83-0) is a chiral phosphoric acid derivative with the molecular formula C12H17O5P and a molecular weight of 272.23. This compound is a valuable reagent primarily utilised in asymmetric synthesis for the resolution of amines, amino acids, and amino alcohols. Its specific stereochemistry makes it instrumental in chiral separations and the synthesis of enantiomerically pure compounds.
- Synonyms
- 2-dioxaphosphorinane 2-oxide,98674-83-0, C12H17O5P
Resolution of Amines
This chiral phosphoric acid serves as an effective resolving agent for racemic mixtures of amines. It selectively forms diastereomeric salts, enabling the separation of enantiomers.
Amino Acid Separation
The compound is employed in the chiral resolution of amino acids, facilitating the isolation of specific enantiomers essential for pharmaceutical and biochemical applications.
Amino Alcohol Resolution
It is also applicable for the enantiomeric separation of amino alcohols, providing a key tool for accessing chiral building blocks in organic synthesis.
Asymmetric Synthesis
As a chiral building block and reagent, it contributes to the development of asymmetric synthetic methodologies, enabling the stereoselective formation of new chiral centres.
| Molecular weight | 272.23 |
|---|---|
| Empirical formula | C12H17O5P |
| Assay | 97% |
| Optical activity | [α]22/D −59°, c = 1 in methanol |
| Storage temperature | 2-8°C |
| Application | Chiral phosphoric acid used for the resolution of amines, amino acids, and amino alcohols.1,2,3 |
| Melting point | 194-196 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (S)-(−)-2-Hydroxy-4-(2-methoxyphenyl)-5,5-dimethyl-1,3,2-dioxaphosphorinane 2-oxide used for?
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This compound is primarily used as a chiral phosphoric acid for the resolution of amines, amino acids, and amino alcohols in asymmetric synthesis.
What is the CAS number and molecular formula?
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The CAS number is 98674-83-0, and the molecular formula is C12H17O5P.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this chemical with an assay of 97%. It is supplied as a research or technical grade material and is not represented as USP, BP, or EP grade.
How should this chemical be handled and stored?
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This compound is classified as a warning substance, causing skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). Handle with appropriate personal protective equipment including a dust mask (type N95), eyeshields, and gloves. Store at 2-8°C.
Is this product available for export?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, and this product can be packed and shipped internationally.
How can I request a sample or quote?
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To request a sample or a quotation for (S)-(−)-2-Hydroxy-4-(2-methoxyphenyl)-5,5-dimethyl-1,3,2-dioxaphosphorinane 2-oxide, please contact our sales team through the website or by phone.
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