(S)-(−)-2-[2-(Diphenylphosphino)phenyl]-4-isopropyl-2-oxazoline
(S)-(−)-2-[2-(Diphenylphosphino)phenyl]-4-isopropyl-2-oxazoline (CAS 148461-14-7) is a chiral oxazoline phosphine ligand with the molecular formula C24H24NOP and a molecular weight of 373.43 g/mol. This compound is primarily utilised as a privileged ligand in asymmetric synthesis, facilitating enantioselective catalytic transformations. Its well-defined stereochemistry and phosphine functionality make it a valuable tool for developing stereospecific chemical processes.
- IUPAC
- (S)-(−)-2-[2-(Diphenylphosphino)phenyl]-4,5-dihydro-4-isopropyloxazole
![(S)-(−)-2-[2-(Diphenylphosphino)phenyl]-4-isopropyl-2-oxazoline (C24H24NOP) — chemical structure, CAS 148461-14-7; Chemistry, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F148461-14-7.png&w=3840&q=75)
Asymmetric Catalysis
This chiral phosphine oxazoline ligand is extensively employed in transition metal-catalysed asymmetric reactions. It enables the synthesis of chiral molecules with high enantiomeric excess, crucial for pharmaceuticals and fine chemicals.
Homogeneous Catalysis
As a component in homogeneous catalytic systems, it participates in a range of transformations including asymmetric hydrogenation, allylic alkylation, and Heck reactions. Its structure is optimised for binding to metal centres, influencing reactivity and selectivity.
Ligand Design and Development
The PHOX (phosphine-oxazoline) scaffold is a well-established class of privileged ligands. This specific derivative, with an isopropyl substituent, offers tailored steric and electronic properties for specific catalytic applications.
| Molecular weight | 373.43 |
|---|---|
| Empirical formula | C24H24NOP |
| Assay | ≥97.0% (CHN) |
| Optical activity | [α]20/D −48±3°, c = 1% in chloroform |
| Melting point | 85-90 °C |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (S)-(−)-2-[2-(Diphenylphosphino)phenyl]-4-isopropyl-2-oxazoline used for?
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This compound is a chiral ligand used primarily in asymmetric synthesis and homogeneous catalysis to facilitate enantioselective transformations.
What is the CAS number and formula for this chemical?
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The CAS number is 148461-14-7, and the empirical formula is C24H24NOP.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this product with an assay of ≥97.0% (CHN). This is a research-grade chemical and TSS does not represent it as USP, BP, EP, or other pharmacopoeia grades.
How should (S)-(−)-2-[2-(Diphenylphosphino)phenyl]-4-isopropyl-2-oxazoline be handled?
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Handle with appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is recommended. Refer to the Safety Data Sheet for detailed handling instructions.
Is this chemical hazardous?
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According to the WGK Germany classification, this compound is rated 3, indicating it is hazardous to water. Consult the Safety Data Sheet for full hazard information.
How is this product packed and shipped?
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Tech Serve Solutions, as a global supplier and exporter, ensures appropriate packaging and shipping methods compliant with international regulations for fine chemicals.
How can I request a sample or quote for this product?
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Please contact our sales team via the website or direct email to request a sample or a formal quotation for (S)-(−)-2-[2-(Diphenylphosphino)phenyl]-4-isopropyl-2-oxazoline.
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