(S)-(−)-3,3,3-Trifluoro-1,2-epoxypropane
(S)-(−)-3,3,3-Trifluoro-1,2-epoxypropane (CAS: 130025-34-2) is a chiral epoxide with the molecular formula C3H3F3O and a molecular weight of 112.05 g/mol. This highly flammable liquid serves as a critical precursor in asymmetric synthesis. It is instrumental in generating trifluoromethyl chiral auxiliaries, which are essential for achieving high diastereoselectivity in reactions such as the Simmons-Smith cyclopropanation, making it a valuable building block for complex molecule synthesis.
- IUPAC
- (S)-(−)-2-(Trifluoromethyl)oxirane
- Synonyms
- (S)-(−)-2-(Trifluoromethyl)oxirane2-epoxypropane,130025-34-2, C3H3F3O
Chiral Auxiliary Precursor
This compound is a key precursor for the synthesis of trifluoromethyl chiral auxiliaries. These auxiliaries are crucial for directing the stereochemical outcome of various organic transformations.
Asymmetric Synthesis
It enables highly diastereoselective Simmons-Smith cyclopropanation reactions. This makes it indispensable for the construction of chiral cyclopropane rings, important motifs in many pharmaceuticals and natural products.
Organic Building Block
As a functionalized chiral epoxide, it is a versatile building block in organic synthesis, allowing for the introduction of a trifluoromethyl group and a chiral center into target molecules.
| Molecular weight | 112.05 |
|---|---|
| Empirical formula | C3H3F3O |
| Assay | 97% |
| Boiling point | 25-32 °C |
| Density | 1.294 g/mL at 25 °C |
| Refractive index | n20/D <1.300 |
| Storage temperature | −20°C |
| Application | Precursor to a trifluoromethyl chiral auxiliary which promotes a highly diastereoselective Simmons-Smith cyclopropanation.1 |
Hazard statements
- H224Extremely flammable liquid and vapour
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US) |
|---|---|
| Flash point | -26 °C / -14.8 °F |
| Transport (UN / ADR) | UN 1993A 3 / PGI |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F+ |
| Risk statements (R) | 12 |
| Safety statements (S) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (S)-(−)-3,3,3-Trifluoro-1,2-epoxypropane used for?
+
(S)-(−)-3,3,3-Trifluoro-1,2-epoxypropane is used as a precursor to trifluoromethyl chiral auxiliaries, which promote highly diastereoselective Simmons-Smith cyclopropanation reactions, serving as a valuable chiral building block in organic synthesis.
What is the CAS number and formula for (S)-(−)-3,3,3-Trifluoro-1,2-epoxypropane?
+
The CAS number is 130025-34-2, and its empirical formula (Hill notation) is C3H3F3O.
What grade and purity does Tech Serve Solutions supply for (S)-(−)-3,3,3-Trifluoro-1,2-epoxypropane?
+
Tech Serve Solutions supplies (S)-(−)-3,3,3-Trifluoro-1,2-epoxypropane with an assay of 97%. TSS does not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
What are the main safety concerns when handling (S)-(−)-3,3,3-Trifluoro-1,2-epoxypropane?
+
This compound is extremely flammable (H224) and requires careful handling. It is essential to use appropriate personal protective equipment, including eyeshields, face shields, and gloves, along with a suitable respirator. Store at -20°C away from ignition sources.
How is (S)-(−)-3,3,3-Trifluoro-1,2-epoxypropane packed and shipped?
+
This chemical is shipped as a flammable liquid (UN 1993A 3 / PGI) under controlled conditions, adhering to all relevant transport regulations. It is exported globally by Tech Serve Solutions.
How can I request a quote or sample for (S)-(−)-3,3,3-Trifluoro-1,2-epoxypropane?
+
To request a quote or sample, please contact our sales team through the Tech Serve Solutions website, providing your contact details and the product's CAS number (130025-34-2).
▶ Related products
1-(2-Fluorobenzyl)piperazine
C11H15FN2
Chemical Synthesis
1-(2-Fluorophenyl)biguanide hydrochloride
Chemical Synthesis
1-(2-Fluorophenyl)cyclopropanecarboxylic acid
C10H9FO2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine
C10H13FN2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine monohydrochloride
C10H13FN2 · HCl
Chemical Synthesis
1-(2-Furoyl)-1H-benzotriazole
C11H7N3O2
Chemical Synthesis
1-(2-Furoyl)piperazine
C9H12N2O2
Chemical Synthesis
1-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione
Chemical Synthesis
▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis