(S)-(−)-2-Methyl-CBS-oxazaborolidine
(S)-(−)-2-Methyl-CBS-oxazaborolidine (CAS: 112022-81-8, C18H20BNO) is a chiral catalyst primarily utilised in asymmetric synthesis. With a molecular weight of 277.17 g/mol, this oxazaborolidine derivative is instrumental in directing enantioselective reductions, making it a valuable reagent in complex organic synthesis and pharmaceutical development. It is supplied as a 1 M solution in toluene.
Asymmetric Synthesis
This compound serves as a crucial chiral catalyst in asymmetric synthesis, enabling the stereoselective formation of chiral molecules. It is widely employed in enantioselective reductions of various functional groups.
Pharmaceutical Intermediate Production
Its ability to facilitate enantioselective transformations makes it a key reagent in the synthesis of complex pharmaceutical intermediates where specific stereochemistry is critical for biological activity.
Chiral Catalyst
As a member of the CBS (Corey-Bakshi-Shibata) catalyst family, it excels in catalysing enantioselective borane reductions of ketones and other prochiral substrates.
Organic Synthesis
It is a versatile tool for synthetic chemists, facilitating challenging stereochemical control in the preparation of intricate organic molecules.
| Molecular weight | 277.17 |
|---|---|
| Empirical formula | C18H20BNO |
| Assay | ≥95.0% |
| Boiling point | 111 °C |
| Density | 0.929 g/mL at 25 °C |
| Concentration | 1 M in toluene |
| Storage temperature | room temp |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (S)-(−)-2-Methyl-CBS-oxazaborolidine used for?
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(S)-(−)-2-Methyl-CBS-oxazaborolidine is primarily used as a chiral catalyst in asymmetric synthesis, particularly for the enantioselective reduction of ketones and other prochiral substrates.
What are the CAS number and chemical formula for (S)-(−)-2-Methyl-CBS-oxazaborolidine?
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The CAS number is 112022-81-8 and the chemical formula is C18H20BNO.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies (S)-(−)-2-Methyl-CBS-oxazaborolidine with an assay of ≥95.0%. This product is not represented as USP, BP, or EP grade.
How should (S)-(−)-2-Methyl-CBS-oxazaborolidine be handled safely?
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Handle with appropriate personal protective equipment including a dust mask type N95 (US), eyeshields, and gloves. Ensure adequate ventilation. Avoid breathing vapours or mist. It is classified as a Warning with hazards H315 (causes skin irritation), H319 (causes serious eye irritation), and H335 (may cause respiratory irritation).
How is (S)-(−)-2-Methyl-CBS-oxazaborolidine typically supplied and shipped?
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This chemical is supplied as a 1 M solution in toluene and is stored at room temperature. TSS exports globally.
How can I request a sample or quote for (S)-(−)-2-Methyl-CBS-oxazaborolidine?
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Please contact our sales team via the website or by phone to request a sample or a formal quotation for (S)-(−)-2-Methyl-CBS-oxazaborolidine.
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