(R)-SIPHOS
(R)-SIPHOS, CAS 443965-14-8, is a chiral phosphoramidite ligand with the molecular formula C19H20NO2P and a molecular weight of 325.34 g/mol. This compound plays a crucial role in asymmetric synthesis, particularly in catalysing stereoselective reactions. Its specific stereochemistry allows for high enantioselectivity, making it a valuable reagent in the synthesis of complex chiral molecules.
- IUPAC
- (11aR)-(+)-10,11,12,13-Tetrahydrodiindeno[7,1-de:1′,7′-fg][1,3,2]dioxaphosphocin-5-dimethylamine,N-Dimethyl-[(R)-1,1′-spirobiindane-7,7′-diyl]phosphoramidite
Asymmetric Catalysis
(R)-SIPHOS is employed as a chiral ligand in transition metal-catalysed reactions to induce enantioselectivity. It is particularly effective in facilitating asymmetric transformations, leading to the formation of chiral products with high optical purity.
Synthesis of Pharmaceutical Intermediates
The ability of (R)-SIPHOS to control stereochemistry makes it an important tool in the synthesis of enantiomerically pure intermediates for pharmaceuticals. Its application can streamline complex synthetic routes, improving efficiency and yield of desired stereoisomers.
Chiral Ligand Development
As a representative of chiral phosphoramidite ligands, (R)-SIPHOS contributes to the ongoing development and understanding of ligand design in asymmetric catalysis. Its structural features offer insights into structure-activity relationships for chiral induction.
| Molecular weight | 325.34 |
|---|---|
| Empirical formula | C19H20NO2P |
| Assay | 97% |
| Optical activity | [α]22/D +480°, c = 1 in chloroform |
| Melting point | 92-96 °C |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (R)-SIPHOS used for?
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(R)-SIPHOS is primarily used as a chiral ligand in asymmetric catalysis to achieve high enantioselectivity in chemical transformations, particularly in the synthesis of chiral molecules and pharmaceutical intermediates.
What is the CAS number and formula for (R)-SIPHOS?
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The CAS number for (R)-SIPHOS is 443965-14-8, and its molecular formula is C19H20NO2P.
What grade and purity does Tech Serve Solutions supply for (R)-SIPHOS?
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Tech Serve Solutions supplies (R)-SIPHOS with a purity of 97%. This product is supplied for research and chemical synthesis purposes and is not represented as USP, BP, EP, or any other pharmacopoeia grade.
What are the safety and handling precautions for (R)-SIPHOS?
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(R)-SIPHOS requires appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is recommended. Due to its classification (WGK Germany 3), handle with care in a well-ventilated area, avoiding contact with skin, eyes, and clothing.
How is (R)-SIPHOS packaged and exported?
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(R)-SIPHOS is carefully packaged to maintain its integrity during transit. Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, ensuring compliant and secure international shipments.
How can I request a sample or quote for (R)-SIPHOS?
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To request a sample or a quotation for (R)-SIPHOS, please contact our sales team through the TSS website or by calling our office. Please reference the product name and CAS number (443965-14-8) in your request.
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