(R)-SIPHOS-PE
(R)-SIPHOS-PE, CAS 500997-69-3, is a complex chiral phosphoramidite ligand with the formula C33H32NO2P and a molecular weight of 505.59 g/mol. This compound is primarily utilised as a highly effective chiral catalyst in asymmetric synthesis. Its specific stereochemistry and structural features enable the enantioselective induction of various chemical transformations, making it a valuable tool for the preparation of enantiomerically pure compounds in research and development settings.
- IUPAC
- (11aR)-(+)-10,11,12,13-Tetrahydrodiindeno[7,1-de:1′, 7′-fg][1,3,2]dioxaphosphocin-5-bis[(R)-1-phenylethyl]amine,N-Di[(R)-1-phenylethyl]-[(R)-1,1′-spirobiindane-7,7′-diyl]-phosphoramidite
Asymmetric Catalysis
(R)-SIPHOS-PE serves as a chiral ligand in transition metal-catalyzed asymmetric reactions. It facilitates the formation of specific enantiomers in various synthetic processes, crucial for pharmaceutical and fine chemical industries.
Enantioselective Synthesis
This phosphoramidite is employed to achieve high levels of enantioselectivity in reactions such as asymmetric hydrogenation, hydroformylation, and conjugate additions. Its application leads to the production of chiral molecules with defined stereochemistry.
Ligand Development
As a sophisticated chiral ligand, (R)-SIPHOS-PE is a subject of study and application in the development of new catalytic systems. Researchers utilise it to explore novel asymmetric transformations and optimise existing catalytic methods.
| Molecular weight | 505.59 |
|---|---|
| Empirical formula | C33H32NO2P |
| Assay | 97% |
| Optical activity | [α]22/D +337°, c = 1 in chloroform |
| Storage temperature | −20°C |
| Melting point | 90-96 °C |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36/37 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (R)-SIPHOS-PE primarily used for?
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(R)-SIPHOS-PE is primarily used as a chiral ligand in asymmetric catalysis for enantioselective synthesis, enabling the preparation of chirally pure compounds.
What is the CAS number and formula for (R)-SIPHOS-PE?
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The CAS number for (R)-SIPHOS-PE is 500997-69-3 and its empirical formula is C33H32NO2P.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies (R)-SIPHOS-PE with an assay of 97%. We do not represent this product as meeting USP, BP, EP, or other pharmacopoeial standards, as such grades are not specified in the product data.
What are the safety and handling precautions for (R)-SIPHOS-PE?
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(R)-SIPHOS-PE is classified with GHS07 signal word 'Warning' and carries hazard statements H315, H319, and H335, indicating it can cause skin irritation, serious eye irritation, and respiratory irritation. Recommended personal protective equipment includes a dust mask type N95 (US), eyeshields, and gloves. Handle in a well-ventilated area and avoid dust formation.
How is (R)-SIPHOS-PE packed and shipped?
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(R)-SIPHOS-PE is typically stored at -20°C. Tech Serve Solutions ensures appropriate packaging for safe handling, storage, and international export of this chemical.
How can I request a sample or quote for (R)-SIPHOS-PE?
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To request a sample or a quote for (R)-SIPHOS-PE, please contact our sales department through the website or by phone, providing your specific requirements and shipping details.
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