(R)-α,α-Bis(3,5-dimethylphenyl)-2-pyrrolidinemethanol
(R)-α,α-Bis(3,5-dimethylphenyl)-2-pyrrolidinemethanol (CAS 948595-01-5) is a chiral organocatalyst with the molecular formula C21H27NO and a molecular weight of 309.45. This compound is crucial in asymmetric synthesis, enabling the stereoselective formation of chiral molecules. Its structure, featuring a pyrrolidine ring and sterically hindered aryl groups, facilitates high enantioselectivity in various catalytic applications. It is supplied by Tech Serve Solutions for research and development purposes.
- IUPAC
- (R)-(+)-2-[Bis(3,5-dimethylphenyl)hydroxymethyl]pyrrolidine
- Synonyms
- 948595-01-5, C21H27NO, (R)-(+)-2-[Bis(3,5-dimethylphenyl)hydroxymethyl]pyrrolidine
Chiral Catalyst in Asymmetric Synthesis
This compound acts as a highly effective chiral catalyst, promoting enantioselective transformations. It is particularly useful in reactions where controlling the stereochemistry of the product is paramount, such as the synthesis of enantiomerically pure pharmaceuticals and fine chemicals.
Ligand in Organometallic Catalysis
As a proline-based derivative, it can serve as a chiral ligand in organometallic catalysis. Its unique structural features can induce chirality in metal-catalyzed reactions, leading to enantioenriched products.
Reagent for Stereoselective Reactions
It is employed as a key reagent in various stereoselective organic reactions. Its application aids in the synthesis of complex molecules with defined stereocentres, which are often critical in drug discovery and development.
| Molecular weight | 309.45 |
|---|---|
| Empirical formula | C21H27NO |
| Assay | ≥99% (HPLC) |
| Optical purity | ee: 99% (HPLC) |
| Storage temperature | 2-8°C |
| Melting point | 98-101 °C |
Hazard statements
- H302Harmful if swallowed
- H400Very toxic to aquatic life
Precautionary statements
- P273Avoid release to the environment
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Transport (UN / ADR) | UN 2811 6.1 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn,N |
| Risk statements (R) | 22-50/53 |
| Safety statements (S) | 60-61 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (R)-α,α-Bis(3,5-dimethylphenyl)-2-pyrrolidinemethanol used for?
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This compound is primarily used as a chiral catalyst and ligand in asymmetric synthesis to achieve high enantioselectivity in chemical reactions, especially in the preparation of enantiomerically pure compounds.
What is the CAS number and chemical formula for this product?
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The CAS number is 948595-01-5 and the empirical formula is C21H27NO.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this product with an assay of ≥99% (HPLC) and an optical purity of ee: 99% (HPLC). TSS does not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
How should (R)-α,α-Bis(3,5-dimethylphenyl)-2-pyrrolidinemethanol be handled?
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This compound is classified under GHS07 and GHS09 with a signal word of Warning. It carries hazard statements H302 (Harmful if swallowed) and H400 (Very toxic to aquatic life). Recommended personal protective equipment includes a dust mask type N95 (US), eyeshields, and gloves. Ensure it is not released into the environment (P273).
Is this chemical controlled or scheduled?
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This product is not indicated as a controlled or scheduled substance in the provided data.
How is this chemical packed, shipped, or exported?
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This chemical is classified under UN 2811 6.1 / PGIII for transport. It should be stored at 2-8°C and is labelled with European hazard codes Xn, N and risk statements 22-50/53. TSS ensures compliant packing and export procedures.
How can I request a sample or a quote for this chemical?
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To request a sample or a quote, please contact our sales team through the website or by phone. Provide the product name and CAS number (948595-01-5) for prompt service.
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