(R)-α,α-Bis(3,5-dimethylphenyl)-2-pyrrolidinemethanol trimethylsilyl ether hydrochloride
(R)-α,α-Bis(3,5-dimethylphenyl)-2-pyrrolidinemethanol trimethylsilyl ether hydrochloride (CAS: 1217450-13-9) is a chiral organocatalyst supplied by Tech Serve Solutions. With a molecular weight of 418.09 g/mol, this proline-derived compound is primarily utilised in asymmetric synthesis. It functions as an effective catalyst in various enantioselective transformations, aiding in the creation of chiral molecules with high optical purity.
- IUPAC
- (R)-α,α-Bis(3,5-dimethylphenyl)prolinol-trimethylsilyl ether hydrobromide,(R)-2-[Bis(3,5-dimethylphenyl)(trimethylsilyloxy)methyl]pyrrolidine hydrochloride
- Synonyms
- 1217450-13-9C24H35NOSi · HCl(R)-2-[Bis(3,5-dimethylphenyl)(trimethylsilyloxy)methyl]pyrrolidine hydrochloride
Enantioselective Ene Reactions
This compound serves as a key catalyst for enantioselective ene reactions, facilitating the stereoselective formation of carbon-carbon bonds.
Dienamine Catalysis
It is employed as a catalyst in dienamine catalysis, enabling asymmetric transformations through enamine intermediates.
Alpha-Sulfenylation of Aldehydes
The reagent catalyses the enantioselective alpha-sulfenylation of aldehydes, a crucial step in the synthesis of chiral sulfur-containing compounds.
| Molecular weight | 418.09 |
|---|---|
| Empirical formula | C24H35NOSi · HCl |
| Assay | ≥96.5% (HPLC)97% |
| Optical purity | enantiomeric excess: ≥96.5% (HPLC) |
| Storage temperature | 2-8°C |
| Application | Catalyst for enantioselective ene reaction1; dienamine catalysis2; catalyst for alpha-sulfenylation of aldehydes3 |
| Melting point | 159-163 °C |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (R)-α,α-Bis(3,5-dimethylphenyl)-2-pyrrolidinemethanol trimethylsilyl ether hydrochloride used for?
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This compound is primarily used as a chiral catalyst in asymmetric synthesis, including enantioselective ene reactions, dienamine catalysis, and the alpha-sulfenylation of aldehydes.
What are the CAS number and formula for this product?
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The CAS number is 1217450-13-9, and the empirical formula is C24H35NOSi · HCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this product with an assay of ≥96.5% (HPLC) and an optical purity (enantiomeric excess) of ≥96.5% (HPLC). It is supplied as a technical/research grade chemical and is not represented as USP, BP, or EP.
What are the safety and handling considerations for this chemical?
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This compound is classified with GHS07 signal word 'Warning' and has hazard statements H315, H319, and H335, indicating it may cause skin irritation, serious eye irritation, and respiratory irritation. Recommended personal protective equipment includes a dust mask (N95), eyeshields, and gloves. Ensure adequate ventilation.
How is this product packed, shipped, and exported?
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Tech Serve Solutions, as a specialist global supplier and exporter, ensures appropriate packaging and compliance with international shipping regulations for chemicals like this one.
How can I request a sample or quote for this chemical?
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To request a sample or a quote, please use the contact form on the Tech Serve Solutions website or contact our sales department directly.
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