2,2-Dimethoxypropane
2,2-Dimethoxypropane (CAS: 77-76-9) is a versatile organic compound with the linear formula (CH3)2C(OCH3)2 and a molecular weight of 104.15 g/mol. This clear, colourless liquid is primarily utilised as a protecting agent for diols and as a dehydrating agent in organic synthesis. Its ability to rapidly and reversibly form acetals makes it valuable in various chemical transformations.
- IUPAC
- Acetone dimethyl acetal
- Synonyms
- Acetone dimethyl acetalDimethylketal2,2-Dimethoxy-propanPropane, 2,2-dimethoxy-

Protecting Group Chemistry
2,2-Dimethoxypropane serves as an effective reagent for the protection of 1,2- and 1,3-diols as their corresponding acetals. This protection strategy is widely employed in multi-step organic syntheses where selective functionalisation is required.
Dehydrating Agent
It functions as a potent dehydrating agent, efficiently removing water from reaction mixtures. This property is particularly useful in reactions that are sensitive to the presence of water, such as acetal or ketal formation.
Derivatisation Reagent
The compound can be used to derivatise molecules containing hydroxyl groups, facilitating their analysis or manipulation. It is also used in the synthesis of other chemical intermediates.
| Molecular weight | 104.15 |
|---|---|
| Linear formula | (CH3)2C(OCH3)2 |
| Assay | 98% |
| Boiling point | 83 °C(lit.) |
| Density | 0.847 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.378(lit.) |
| Vapour pressure | 60 mmHg (15.8 °C) |
| Vapour density | 3.59 (vs air) |


Hazard statements
- H225Highly flammable liquid and vapour
- H319Causes serious eye irritation
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | -10 °C / 14 °F |
| Transport (UN / ADR) | UN 1993BE 3 / PGII |
| Water hazard class (WGK, DE) | 2 |
| Hazard codes (EU) | F,Xi |
| Risk statements (R) | 11-36 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2,2-Dimethoxypropane used for?
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2,2-Dimethoxypropane (CAS: 77-76-9) is primarily used as a protecting group for diols and as a dehydrating agent in organic synthesis. It is also utilised in derivatisation procedures.
What are the CAS number and formula for 2,2-Dimethoxypropane?
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The CAS number for 2,2-Dimethoxypropane is 77-76-9, and its linear formula is (CH3)2C(OCH3)2.
What grade and purity does Tech Serve Solutions supply for 2,2-Dimethoxypropane?
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Tech Serve Solutions supplies 2,2-Dimethoxypropane with an assay of 98%. We do not represent this product as USP, BP, or EP grade unless explicitly stated in the product documentation.
How should 2,2-Dimethoxypropane be handled safely?
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2,2-Dimethoxypropane is a highly flammable liquid and vapour (H225) and causes serious eye irritation (H319). Handle with appropriate personal protective equipment, including safety glasses and gloves, in a well-ventilated area, away from ignition sources. Refer to the Safety Data Sheet for full handling instructions.
How is 2,2-Dimethoxypropane packed and shipped?
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2,2-Dimethoxypropane is shipped as a UN 1993, Flammable Liquid, Class 3, Packing Group II, under proper shipping name BE 3. TSS exports this chemical globally, adhering to all relevant transportation regulations.
How can I request a sample or a quote for 2,2-Dimethoxypropane?
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Please contact our sales team via the website or direct email to request a sample or a formal quotation for 2,2-Dimethoxypropane.
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